Technology Process of (S)-6-methoxy-9-oxo-N-(1-(p-tolyl)ethyl)-9H-xanthene-2-carboxamide
There total 8 articles about (S)-6-methoxy-9-oxo-N-(1-(p-tolyl)ethyl)-9H-xanthene-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
enantioselective reaction;
DOI:10.1016/j.bmc.2013.12.042
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: copper(l) iodide; dimethylaminoacetic acid; caesium carbonate / 1,4-dioxane / 14 h / 90 °C / Inert atmosphere; Sealed tube
2.1: sodium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C
3.1: phosphorus pentoxide / 22 h / 20 °C
3.2: 19 h / Reflux
4.1: sodium hydroxide / methanol; dichloromethane / 22 h / 20 °C
5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.5 h / 20 °C
With
copper(l) iodide; dimethylaminoacetic acid; phosphorus pentoxide; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
1.1: |Ullmann Condensation;
DOI:10.1016/j.ejmech.2012.06.049
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / 17 h / Reflux
2.1: copper(l) iodide; dimethylaminoacetic acid; caesium carbonate / 1,4-dioxane / 14 h / 90 °C / Inert atmosphere; Sealed tube
3.1: sodium hydroxide / tetrahydrofuran; methanol / 18 h / 20 °C
4.1: phosphorus pentoxide / 22 h / 20 °C
4.2: 19 h / Reflux
5.1: sodium hydroxide / methanol; dichloromethane / 22 h / 20 °C
6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.5 h / 20 °C
With
copper(l) iodide; dimethylaminoacetic acid; phosphorus pentoxide; sulfuric acid; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;
2.1: |Ullmann Condensation;
DOI:10.1016/j.ejmech.2012.06.049