AZIRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: AZIRIDINE-2-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 5950-34-5
• Molecular Formula: C₄H₇NO₂
• Molecular Weight: 101.105
• Hs Code.: 2933990090
• Mol file: 5950-34-5.mol

Synonyms:2-Carbomethoxyaziridine;Methyl 2-aziridinecarboxylate;

Chemical Property of AZIRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Refractive Index: 1.4400-1.4440
• Boiling Point: 117.9 °C at 760 mmHg
• PKA: 5.76±0.40(Predicted)
• Flash Point: 25.1 °C
• PSA: 48.24000
• Density: 1.163g/cm³
• LogP: -0.54000
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99.0% ^*data from raw suppliers

MethylAziridine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AZIRIDINE-2-CARBOXYLIC ACID METHYL ESTER

There total 7 articles about AZIRIDINE-2-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 1-tritylaziridine-2-carboxylate (76357-18-1) → methyl aziridine-2-carboxylate (5950-34-5,118396-26-2,151526-74-8,151526-75-9)

Guidance literature:

With trifluoroacetic acid; In methanol; dichloromethane; for 3.33h; Inert atmosphere;

DOI:10.1080/00397911.2014.965328

Reference yield: 82.0%

(R,S)-methyl N-(t-butoxycarbonyl)aziridine-2-carboxylate (181212-90-8) → methyl aziridine-2-carboxylate (5950-34-5,118396-26-2,151526-74-8,151526-75-9)

Guidance literature:

With trifluoroacetic acid; In methanol; dichloromethane; for 3.33h; Inert atmosphere;

DOI:10.1080/00397911.2014.965328

Reference yield: 82.0%

L-1-Benzyloxycarbonylaziridine-2-carboxylic acid methyl ester (170701-87-8) → methyl aziridine-2-carboxylate (5950-34-5,118396-26-2,151526-74-8,151526-75-9)

Guidance literature:

With trifluoroacetic acid; In methanol; dichloromethane; for 3.33h; Inert atmosphere;

DOI:10.1080/00397911.2014.965328

upstream raw materials:

Methyl 2,3-dibromopropionate

methyl 1-tritylaziridine-2-carboxylate

methyl (2S)-N-tritylaziridine-2-carboxylate

(R,S)-methyl N-(t-butoxycarbonyl)aziridine-2-carboxylate

Downstream raw materials:

1-Diethylcarbamoyl-aziridine-2-carboxylic acid methyl ester

N,N-Bis(2-methoxycarbonylaziridinocarbonyl)-p-phenylene-diamine

methyl 1-acetylaziridine-2-carboxylate

1-(2-cyanoethyl)aziridine-2-carboxylic acid methyl ester

Refernces

• 1、 Schjoeth-Eskesen, Christina,Hansen, Paul Robert,Kjaer, Andreas,Gillings, Nic. "Efficient regioselective ring opening of activated aziridine-2-carboxylates with [18F]fluoride". . p. 65 - 71. Retrieved 2015/03/04.
• 2、 Bucciarelli, Maria,Forni, Arrigo,Moretti, Irene,Prati, Fabio,Torre, Giovanni. "Candida cylindracea Lipase-Catalysed Hydrolysis of Methyl Aziridine-2-carboxylates and 2,3-dicarboxylates". . p. 3041 - 3046. Retrieved 2007/10/02.