Methyl 2-(2-methylphenoxymethyl)phenylglyoxylate

Base Information

• Chemical Name: Methyl 2-(2-methylphenoxymethyl)phenylglyoxylate
• CAS No.: 143211-10-3
• Molecular Formula: C17H16O4
• Molecular Weight: 284.312
• Hs Code.: 2918990090
• Mol file: 143211-10-3.mol

Synonyms:Methyl 2-oxo-2-(2-((o-tolyloxy)methyl)phenyl)acetate;methyl 2-(2-methylphenoxymethyl)phenylglyoxylate;2-oxo-2-(((o-tolyl)oxymethyl)phenyl)acetic acid methyl ester;methyl 2-oxo-2-[2-methylphenoxymethyl]phenylacetate;

Chemical Property of Methyl 2-(2-methylphenoxymethyl)phenylglyoxylate

Chemical Property:

• Melting Point: 53-55 °C
• Boiling Point: 425.436 °C at 760 mmHg
• Flash Point: 188.131 °C
• PSA: 52.60000
• Density: 1.175 g/cm³
• LogP: 2.92970

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2-oxo-2-(2-((o-tolyloxy)methyl)phenyl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(2-methylphenoxymethyl)phenylglyoxylate

There total 11 articles about Methyl 2-(2-methylphenoxymethyl)phenylglyoxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + 2-[(2-methylphenoxy)methyl]benzoyl cyanide (143211-11-4) → 2-oxo-2-(((o-tolyl)oxymethyl)phenyl)acetic acid methyl ester (143211-10-3)

Guidance literature:

With toluene-4-sulfonic acid; In water; 1,2-dichloro-ethane; at 3 - 20 ℃; for 5h; Temperature; Reagent/catalyst;

Reference yield: 77.0%

→ 2-(2-methylphenoxymethyl)-ω-methylsulfinylacetophenone (143358-87-6) + 2-oxo-2-(((o-tolyl)oxymethyl)phenyl)acetic acid methyl ester (143211-10-3)

Guidance literature:

Reference yield: 61.0%

monomethyl oxalyl chloride (5781-53-3) + 2-(2-methylphenoxymethyl)phenylzinc chloride → 2-oxo-2-(((o-tolyl)oxymethyl)phenyl)acetic acid methyl ester (143211-10-3)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 0 ℃; for 4h;

DOI:10.1016/S0040-4020(99)00632-8

upstream raw materials:

monomethyl oxalyl chloride

2-[(2-methylphenoxy)methyl]benzoyl cyanide

tert-butyl methyl ether

methanol

Downstream raw materials:

methyl (E)-2-methoxyimino-2-[2-(o-tolyloxymethyl)phenyl]acetate

methyl (Z)-O-methyloximino-2-[(2-methyl)phenoxymethyl]phenylacetate

methyl E-2-(2-methylphenoxymethyl)phenylglyoxylate oxime

(E)-2-methoxyimino-2-{[2-(2-tolyl)oxymethyl]phenyl}acetic acid

Refernces

• 1、 -. "Synthesis method of 2-(2-methyl phenoxymethyl)-methyl benzoyl formate". Paragraph 0006; 0019-0030. . Retrieved 2019/07/04.
• 2、 Rossi, Renzo,Carpita, Adriano,Pazzi, Piergiorgio,Mannina, Luisa,Valensin, Daniela. "A novel method for the efficient synthesis of methyl 2-oxo-2- arylacetates and its application to the preparation of fungicidal methyl (E)- O-methyloximino-2-arylacetates and their (Z)-stereoisomers". . p. 11343 - 11364. Retrieved 2007/10/03.