1-Isoquinolineacetic acid methyl ester

Base Information

• Chemical Name: 1-Isoquinolineacetic acid methyl ester
• CAS No.: 69582-93-0
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.22
• Hs Code.: 2933499090
• Mol file: 69582-93-0.mol

Synonyms:Methyl1-isoquinolylacetate;

Chemical Property of 1-Isoquinolineacetic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.000194mmHg at 25°C
• Melting Point: 47-48 °C
• Refractive Index: 1.601
• Boiling Point: 328 °C at 760 mmHg
• Flash Point: 152.2 °C
• PSA: 39.19000
• Density: 1.186 g/cm³
• LogP: 1.95030

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl2-(isoquinolin-1-yl)acetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Isoquinolineacetic acid methyl ester

There total 3 articles about 1-Isoquinolineacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(2,4-dinitro-phenyl)-hydrazine (119-26-6) + dimethyl 2-anilino-3-(isoquinolin-1-yl)succinate (316790-99-5) → methyl 2-(isoquinolin-1-yl)acetate (69582-93-0) + 2,4-dinitrophenylhydrazone of methyl glyoxylate (28833-53-6)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 5 - 20 ℃; for 15.5h;

DOI:10.1002/1522-2675(20000906)83:9<2363::AID-HLCA2363>3.0.CO;2-4

Reference yield: 60.0%

(1R,2S,10bR)-3-Phenyl-1,2,3,10b-tetrahydro-pyrazolo[5,1-a]isoquinoline-1,2-dicarboxylic acid dimethyl ester + dimethyl 2-anilino-3-(isoquinolin-1-yl)succinate (316790-99-5) → methyl 2-(isoquinolin-1-yl)acetate (69582-93-0) + dimethyl 2,3-dihydro-6-[(methoxycarbonyl)methyl]-3-phenylpyrazolo[5,1-a]isoquinoline-1,2-dicarboxylate (97746-09-3)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/1522-2675(20000906)83:9<2363::AID-HLCA2363>3.0.CO;2-4

Reference yield: 59.0%

(2,4-dinitro-phenyl)-hydrazine (119-26-6) + (1R,2S,10bR)-3-Phenyl-1,2,3,10b-tetrahydro-pyrazolo[5,1-a]isoquinoline-1,2-dicarboxylic acid dimethyl ester → methyl 2-(isoquinolin-1-yl)acetate (69582-93-0) + 2,4-dinitrophenylhydrazone of methyl glyoxylate (28833-53-6)

Guidance literature:

With hydrogenchloride; In dichloromethane; at -20 ℃; for 48h;

DOI:10.1002/1522-2675(20000906)83:9<2363::AID-HLCA2363>3.0.CO;2-4

upstream raw materials:

(2,4-dinitro-phenyl)-hydrazine

dimethyl 2-anilino-3-(isoquinolin-1-yl)succinate

Downstream raw materials:

isoquinolineacetic acid

dimethyl 2-anilino-3-(isoquinolin-1-yl)succinate

Refernces