1-(2,2-Diethoxyethyl)-3-methoxyurea

Base Information

• Chemical Name: 1-(2,2-Diethoxyethyl)-3-methoxyurea
• CAS No.: 116451-49-1
• Molecular Formula: C₈H₁₈N₂O₄
• Molecular Weight: 206.242
• Hs Code.: 2924199090
• Mol file: 116451-49-1.mol

Synonyms:N-(2,2-Diethoxyethyl)-N'-methoxy-Urea;

Chemical Property of 1-(2,2-Diethoxyethyl)-3-methoxyurea

Chemical Property:

• Melting Point: 56-58 °C(Solv: hexane (110-54-3))
• Refractive Index: 1.441
• PKA: 12.92±0.46(Predicted)
• PSA: 68.82000
• Density: 1.058 g/cm³
• LogP: 1.02790

Purity/Quality:

98%min ^*data from raw suppliers

1-(2,2-Diethoxyethyl)-3-methoxyurea 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2,2-Diethoxyethyl)-3-methoxyurea

There total 4 articles about 1-(2,2-Diethoxyethyl)-3-methoxyurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,2-Diethoxyethyl isocyanate (28558-91-0) + N-methoxylamine hydrochloride (593-56-6) → C8H18N2O4 (116451-49-1)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃; for 0.75h;

DOI:10.1055/s-1987-28169

Reference yield:

ethyl 3,3-diethoxypropanoate (10601-80-6) → C8H18N2O4 (116451-49-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 80 percent / hydrazine hydrate / 2.5 h / Heating

2: aq. HCl, NaNO₂ / CHCl₃ / 0.25 h / -5 °C

3: CHCl₃ / Heating

4: 77 percent / (C₂H₅)3N / CHCl₃ / 0.75 h / 20 °C

With hydrogenchloride; hydrazine hydrate; triethylamine; sodium nitrite; In chloroform;

DOI:10.1055/s-1987-28169

Reference yield:

3,3-Diethoxypropionic hydrazide (6191-93-1) → C8H18N2O4 (116451-49-1)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. HCl, NaNO₂ / CHCl₃ / 0.25 h / -5 °C

2: CHCl₃ / Heating

3: 77 percent / (C₂H₅)3N / CHCl₃ / 0.75 h / 20 °C

With hydrogenchloride; triethylamine; sodium nitrite; In chloroform;

DOI:10.1055/s-1987-28169

upstream raw materials:

2,2-Diethoxyethyl isocyanate

N-methoxylamine hydrochloride

ethyl 3,3-diethoxypropanoate

3,3-Diethoxypropionic hydrazide

Downstream raw materials:

1-Methoxy-2,3-dihydroimidazole-2-one

Refernces