8-BROMO-5-NITROQUINOLINE

Base Information

• Chemical Name: 8-BROMO-5-NITROQUINOLINE
• CAS No.: 139366-35-1
• Molecular Formula: C9H5 Br N2 O2
• Molecular Weight: 253.055
• Hs Code.: 2933499090
• Mol file: 139366-35-1.mol

Synonyms:8-Bromo-5-nitroquinoline

Chemical Property of 8-BROMO-5-NITROQUINOLINE

Chemical Property:

• Melting Point: 136-137 °C
• Boiling Point: 370.5±27.0 °C(Predicted)
• PKA: 0.16±0.29(Predicted)
• PSA: 58.71000
• Density: 1.747±0.06 g/cm3(Predicted)
• LogP: 3.42870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Bromo-5-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BROMO-5-NITROQUINOLINE

There total 4 articles about 8-BROMO-5-NITROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

8-bromoquinoline (16567-18-3) → 8-bromo-5-nitroquinoline (139366-35-1)

Guidance literature:

With nitric acid; In sulfuric acid;

Reference yield: 15.0%

2-bromo 5-nitroaniline (10403-47-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 8-bromo-5-nitroquinoline (139366-35-1)

Guidance literature:

With ferrous(II) sulfate heptahydrate; methanesulfonic acid; sodium 3-nitrobenzenesulfonate; at 125 ℃; for 20h;

DOI:10.1002/chem.201701707

Reference yield:

→ 8-bromo-5-nitroquinoline (139366-35-1)

Guidance literature:

With copper(I) bromide;

upstream raw materials:

8-bromoquinoline

2-bromo 5-nitroaniline

glycerol

Downstream raw materials:

5-nitro-8-piperidino-quinoline

8-bromo-5-aminoquinoline

8-cyano-5-nitroquinoline

Refernces

• 1、 Miyaji, Ryota,Asano, Keisuke,Matsubara, Seijiro. "Induction of Axial Chirality in 8-Arylquinolines through Halogenation Reactions Using Bifunctional Organocatalysts". supporting information. p. 9996 - 10000. Retrieved 2017/08/01.
• 2、 -. "METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF". . . Retrieved 2008/06/13.