4-TRIFLUOROMETHYL-BENZAMIDINE HCL

Base Information

• Chemical Name: 4-TRIFLUOROMETHYL-BENZAMIDINE HCL
• CAS No.: 38980-96-0
• Molecular Formula: C8H8ClF3N2
• Molecular Weight: 224.613
• Hs Code.: 2925290090
• Mol file: 38980-96-0.mol

Synonyms:Benzenecarboximidamide,4-(trifluoromethyl)-, monohydrochloride (9CI);4-(Trifluoromethyl)benzamidinehydrochloride;4-(Trifluoromethyl)phenylamidine hydrochloride;p-(Trifluoromethyl)benzamidine hydrochloride;a,a,a-Trifluoro-p-toluamidinehydrochloride;benzenecarboximidamide, 4-(trifluoromethyl)-, hydrochloride (1:1);4-(Trifluoromethyl)benzenecarboximidamide hydrochloride (1:1);4-(Trifluoromethyl)benzamidine HCl;4-(trifluoromethyl)benzene-1-carboximidamide hydrochloride;

Chemical Property of 4-TRIFLUOROMETHYL-BENZAMIDINE HCL

Chemical Property:

• Vapor Pressure: 0.00247mmHg at 25°C
• Melting Point: 158-161 °C
• Refractive Index: 1.62
• Boiling Point: 253.2 °C at 760 mmHg
• Flash Point: 106.9 °C
• PSA: 49.87000
• Density: 1.46g/cm³
• LogP: 3.59150
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-(Trifluoromethyl)benzamidine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-43
• Safety Statements: 26-37/39-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-TRIFLUOROMETHYL-BENZAMIDINE HCL

There total 4 articles about 4-TRIFLUOROMETHYL-BENZAMIDINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-CF3C6H4CN (455-18-5) → 4-(trifluoromethyl)benzimidamide hydrochloride (38980-96-0)

Guidance literature:

With ammonium chloride; sodium methylate; In methanol; diethyl ether;

Reference yield: 70.0%

4-(trifluoromethyl)benzamidoxime (22179-86-8) → 4-(trifluoromethyl)benzimidamide hydrochloride (38980-96-0)

Guidance literature:

4-(trifluoromethyl)benzamidoxime; With acetic anhydride; acetic acid; at 20 ℃; for 0.5h;

With triethylsilane; palladium dichloride; at 70 - 75 ℃; for 2h;

With hydrogenchloride; In ethanol;

DOI:10.1080/00397911.2010.488307

Reference yield:

4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride (56108-08-8) → 4-(trifluoromethyl)benzimidamide hydrochloride (38980-96-0)

Guidance literature:

With ammonia; In ethanol; at 0 ℃; for 96h;

DOI:10.1021/jm00166a023

upstream raw materials:

4-CF₃C₆H₄CN

4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride

4-(trifluoromethyl)benzamidoxime

Downstream raw materials:

3-chloro-3-(4-trifluoromethylphenyl)diaziridine

3-(p-(trifluoromethyl)phenyl)diazirine

C₈H₆ClF₃N₂

C₈H₄Cl₃F₃N₂

Refernces

• 1、 -. "Glucagon Receptor Modulators". Page/Page column 55. . Retrieved 2012/07/13.
• 2、 -. "Amino piperidine derivatives". . . Retrieved 2008/06/13.