1-deuteriodiphenylmethanol

Base Information

• Chemical Name: 1-deuteriodiphenylmethanol
• CAS No.: 17498-07-6
• Molecular Formula: C₁₃H₁₂O
• Molecular Weight: 185.23
• Mol file: 17498-07-6.mol

Synonyms:1-deuteriodiphenylmethanol

Chemical Property of 1-deuteriodiphenylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-deuteriodiphenylmethanol

There total 18 articles about 1-deuteriodiphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzophenone (119-61-9) → 1-deuteriodiphenylmethanol (17498-07-6)

Guidance literature:

With cadmium selenide; water-d2; triethylamine; In acetonitrile; at 20 ℃; for 12h; Sealed tube; Irradiation; Inert atmosphere;

DOI:10.1039/d1cc02551a

Reference yield: 83.0%

benzophenone (119-61-9) → 1-deuteriodiphenylmethanol (17498-07-6) + tetraphenylethane-1,2-diol (464-72-2)

Guidance literature:

With water-d2; magnesium; ethylene dibromide; In tetrahydrofuran; at 70 ℃; for 2h; Reagent/catalyst; Catalytic behavior; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.9b04536

Reference yield: 50.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + benzophenone (119-61-9) + [2H9]-3-methylbut-2-en-1-ol → 1,1-Diphenylmethanol (91-01-0) + 1-deuteriodiphenylmethanol (17498-07-6) + tetraphenylethane-1,2-diol (464-72-2) + 3-methyl-3-(tetrahydrofuran-2-yl)butan-1-ol-d9

Guidance literature:

tetrahydrofuran; [²H₉]-3-methylbut-2-en-1-ol; With methylmagnesium bromide; In benzene-d6; for 0.5h; Inert atmosphere;

benzophenone; In benzene-d6; at 20 ℃; for 48h; regioselective reaction; Inert atmosphere;

DOI:10.3987/COM-15-S(T)65

upstream raw materials:

benzophenone

ammonium formate-d₁

diphenylmethyl trimethylsilyl ether

(4-bromophenyl)(phenyl)methanone

Downstream raw materials:

benzophenone

[4-²H]biphenyl

4,4-Diphenyl-<1,1,4-D3>butylbromid

4,4-Diphenyl-<1,1,4-D3>butanol

Refernces

• 1、 Stewart. "-". . p. 3057,3058. Retrieved 1957.
• 2、 Li, Xu-Bing,Nan, Xiao-Lei,Tung, Chen-Ho,Wang, Yao,Wu, Li-Zhu. "Site-selective D2O-mediated deuteration of diaryl alcoholsviaquantum dots photocatalysis". supporting information. p. 6768 - 6771. Retrieved 2021/07/13.
• 3、 Chen, Gong,Qiao, Tianjiao,Wang, Yaxin,Zhang, Jian,Zhao, Jianyou. "Tunable System for Electrochemical Reduction of Ketones and Phthalimides". supporting information. p. 3297 - 3302. Retrieved 2021/10/14.