2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester

Base Information

• Chemical Name: 2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester
• CAS No.: 136285-65-9
• Molecular Formula: C14H18N2O6
• Molecular Weight: 310.307
• Mol file: 136285-65-9.mol

Synonyms:Ethyl 2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-3-nitrobenzoate;

Chemical Property of 2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester

Chemical Property:

• Boiling Point: 390.832 °C at 760 mmHg
• PKA: 12.00±0.70(Predicted)
• Flash Point: 190.169 °C
• PSA: 110.45000
• Density: 1.268 g/cm³
• LogP: 3.71470
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-((tert-butoxycarbonyl)amino)-3-nitrobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester

There total 5 articles about 2-[1.1-dimethyl ethyl ethoxy carbonyl]amino-3-nitro benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-carboxy-3-nitrobenzoate (16533-45-2) → ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate (136285-65-9)

Guidance literature:

With thionyl chloride; In dimethylformamide(DMF); dichloromethane; hexane-diethyl ether; water; tert-butyl alcohol; benzene;

Reference yield:

2-Azidocarbonyl-3-nitro-benzoic acid ethyl ester (124341-05-5) + tert-butyl alcohol (75-65-0) → ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate (136285-65-9)

Guidance literature:

In toluene; at 80 - 90 ℃; for 1h;

Reference yield:

3-nitro-phthalic acid-1-ethyl ester-2-chloride (136285-66-0) + tert-butyl alcohol (75-65-0) → ethyl 2-[(N-tert-butoxycarbonyl)amino]-3-nitrobenzoate (136285-65-9) + 2-Azidocarbonyl-3-nitro-benzoic acid ethyl ester (124341-05-5)

Guidance literature:

With Caswell No_. 744A; tetrabutylammonium bromide;

upstream raw materials:

ethyl 2-carboxy-3-nitrobenzoate

3-nitro-phthalic acid-1-ethyl ester-2-chloride

tert-butyl alcohol

3-nitrophthalic acid

Downstream raw materials:

ethyl 2-(N-tert-butoxycarbonyl-N-methyl)amino-3-nitrobenzoate

ethyl 2-ethoxy-3H-benzimidazole-4-carboxylate

1H-benzoimidazole-7-carboxylic acid ethyl ester

ethyl 2-[(N-tert-butoxycarbonyl)-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]biphenyl-4-yl]methyl]amino]-3-nitrobenzoate

Refernces

• 1、 -. "1-(CYCLOHEXYLOXYCARBONYLOXY)ETHYL 2-ETHOXY-1-[[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL]BENZIMIDAZOLE-7-CARBOXYLATE AND COMPOSITIONS AND METHODS OF PHARMACEUTICAL USE THEREOF". . . Retrieved 2008/06/13.