((4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl)dimethanamine

Base Information

• Chemical Name: ((4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl)dimethanamine
• CAS No.: 146092-05-9
• Molecular Formula: C₈H₁₈N₂O₂
• Molecular Weight: 174.243
• European Community (EC) Number: 832-332-4
• Nikkaji Number: J2.968.923G
• Mol file: 146092-05-9.mol

Synonyms:146092-05-9;((4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl)dimethanamine;[(4R,5R)-5-(aminomethyl)-2-propan-2-yl-1,3-dioxolan-4-yl]methanamine;(4R,5R)-4,5-BIS(AMINOMETHYL)-2-ISOPROPYL-1,3-DIOXOLANE;SCHEMBL9120885;(4R,5R)-4,5-bis(Aminomethyl)-2-isklrklg-1,3-dioxolane;MFCD10000453;AKOS006282709;EN300-2585248;A808448;[(4R,5R)-5-(aminomethyl)-2-(propan-2-yl)-1,3-dioxolan-4-yl]methanamine

Chemical Property of ((4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl)dimethanamine

Chemical Property:

• Boiling Point: 261.5 °C at 760 mmHg
• PKA: 9.46±0.29(Predicted)
• Flash Point: 114 °C
• PSA: 70.50000
• Density: 1.01 g/cm³
• LogP: 1.07050
• Storage Temp.: 2-8°C
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 174.136827821
• Heavy Atom Count: 12
• Complexity: 129

Purity/Quality:

99% ^*data from raw suppliers

((4R,5R)-2-Isopropyl-1,3-dioxolane-4,5-diyl)dimethanamine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1OC(C(O1)CN)CN
• Isomeric SMILES: CC(C)C1O[C@@H]([C@H](O1)CN)CN

Technology Process of ((4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl)dimethanamine

There total 7 articles about ((4R,5R)-2-isopropyl-1,3-dioxolane-4,5-diyl)dimethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4S,5S)-4,5-bis(azidomethyl)-2-isopropyl-1,3-dioxolane → (4S,5S)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane (146092-05-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 40 ℃; for 2h; under 2585.7 Torr;

DOI:10.1021/jm00036a013

Reference yield: 96.0%

(4R,5R)-4,5-bis(azidomethyl)-2-isopropyl-1,3-dioxolane → (4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane (146092-05-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 40 ℃; for 2h; under 2585.7 Torr;

DOI:10.1021/jm00036a013

Reference yield:

2,3-O-isobutylidene-L-threitol 1,4-bis(methanesulfonate) → (4S,5S)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane (146092-05-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / NaN₃ / dimethylformamide / 16 h / 100 °C

2: 96 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 40 °C / 2585.7 Torr

With sodium azide; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00036a013

upstream raw materials:

diethyl 2,3-O-isobutylidene-D-tartrate

Refernces

• 1、 -. "Platinum(II) complex and processes for preparing the same". . . Retrieved 2008/06/13.