Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)

Base Information

• Chemical Name: Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)
• CAS No.: 529508-54-1
• Molecular Formula: C7H7N3O
• Molecular Weight: 149.15
• Hs Code.: 2933990090
• Mol file: 529508-54-1.mol

Synonyms:5-Methyl-3H-pyrrolo[2,1-f][1,2,4]triazin-4-one;

Chemical Property of Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)

Chemical Property:

• PSA: 50.16000
• Density: 1.424 g/cm³
• LogP: 0.33100
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Methylpyrrolo[2,1-f][1,2,4]triazin-4(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI)

There total 14 articles about Pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one, 5-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid (310435-15-5) → 5-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (529508-54-1)

Guidance literature:

With phosphoric acid; In water; at 110 ℃; for 18h;

Reference yield: 78.0%

C8H7N3O3 (310435-15-5) → C7H7N3O (529508-54-1)

Guidance literature:

With phosphoric acid; at 125 ℃;

DOI:10.1021/op300252n

Reference yield:

ethyl 1-amino-3-methyl-1H-pyrrole-2-carboxylate (1392140-56-5) + formamidine (463-52-5) → C7H7N3O (529508-54-1)

Guidance literature:

In isopropyl alcohol; at 90 ℃; for 20h;

upstream raw materials:

formic acid

1-amino-2-aminocarbonyl-3-methylpyrrole

3-methylpyrrole

1-amino-3-methyl-1H-pyrrole-2-carbonitrile

Downstream raw materials:

4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine

5-methyl-4-(methylthio)pyrrolo[2,1-f][1,2,4]triazine

Refernces

• 1、 -. "Bromine structural domain inhibitor compound and application thereof". . . Retrieved 2019/08/02.
• 2、 Zheng, Bin,Conlon, David A.,Corbett, R. Michael,Chau, Melissa,Hsieh, Dau-Ming,Yeboah, Agnes,Hsieh, Daniel,Mueslehiddinoglu, Jale,Gallagher, William P.,Simon, Jeffrey N.,Burt, Justin. "Development of a practical synthesis of a functionalized pyrrolo[2,1-f][1,2,4]triazine nucleus". . p. 1846 - 1853. Retrieved 2013/01/15.