4-Benzyloxybenzonitrile

Base Information

• Chemical Name: 4-Benzyloxybenzonitrile
• CAS No.: 52805-36-4
• Molecular Formula: C14H11NO
• Molecular Weight: 209.247
• Hs Code.: 29269090
• Mol file: 52805-36-4.mol

Synonyms:4-BENZYLOXYBENZONITRILE;4-Cyanophenylbenzyl ether

Chemical Property of 4-Benzyloxybenzonitrile

Chemical Property:

• Vapor Pressure: 8.61E-06mmHg at 25°C
• Melting Point: 94 °C
• Refractive Index: 1.597
• Boiling Point: 374 °C at 760 mmHg
• Flash Point: 157.6 °C
• PSA: 33.02000
• Density: 1.14 g/cm³
• LogP: 3.13728
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: almost transparency in hot Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(Benzyloxy)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Benzyloxybenzonitrile

There total 65 articles about 4-Benzyloxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl bromide (100-39-0) + 4-cyanophenol (767-00-0) → 4-benzyloxybenzonitrile (52805-36-4)

Guidance literature:

With sodium carbonate; In acetone; for 16h; Reflux;

DOI:10.1016/j.bmc.2013.10.031

Reference yield: 99.0%

4-cyanophenol (767-00-0) + benzyl chloride (100-44-7) → 4-benzyloxybenzonitrile (52805-36-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield: 99.0%

4-benzyloxybenzyl alcohol (836-43-1) → 4-benzyloxybenzonitrile (52805-36-4)

Guidance literature:

With ammonia; oxygen; In tert-Amyl alcohol; water; at 100 ℃; for 14h; under 3750.38 Torr; Autoclave; High pressure;

DOI:10.1021/acscatal.0c00485

upstream raw materials:

p-benzyloxybenzaldehyde

O-benzyl oxime of 4-nitrobenzaldehyde

benzyl bromide

4-cyanophenol

Downstream raw materials:

4'-benzyloxy-acetophenone

2-(4-benzyloxy-phenyl)-8-methyl[1,2,4]triazolo[1,5-a]pyridine

methyl 4-(benzyloxy)benzimidate hydrochloride

3-(4-benzyloxyphenyl)-1H-1,2,4-triazole

Refernces

• 1、 Chen, Qingqing,Han, Hongwei,Lin, Hongyan,Ma, Xiaopeng,Qi, Jinliang,Wang, Xiaoming,Yang, Yonghua,Zhou, Ziling. "One pot synthesis of aryl nitriles from aromatic aldehydes in a water environment". . p. 24232 - 24237. Retrieved 2021/07/29.
• 2、 -. "EIF4E INHIBITORS AND USES THEREOF". Paragraph 00337; 00358. . Retrieved 2021/09/11.