Technology Process of (S)-benzyl [5-(1,3-dioxoisoindolin-2-yl)-3-oxo-1-phenylpentyl]carbamate
There total 7 articles about (S)-benzyl [5-(1,3-dioxoisoindolin-2-yl)-3-oxo-1-phenylpentyl]carbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-benzyl-trimethylammonium hydroxide;
In
ethyl acetate;
for 16h;
Reflux;
DOI:10.1002/ejoc.201200919
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / methanol; water / 16 h / 20 °C
2.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 20 °C
2.2: 18 h / 20 °C
3.1: tetrahydrofuran / 0.33 h / 0 °C
4.1: N-benzyl-trimethylammonium hydroxide / ethyl acetate / 16 h / Reflux
With
N-benzyl-trimethylammonium hydroxide; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1002/ejoc.201200919
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium carbonate / dichloromethane; water / 16 h / 20 °C
2.1: sodium hydroxide / methanol; water / 16 h / 20 °C
3.1: 1,1'-carbonyldiimidazole / dichloromethane / 0.5 h / 20 °C
3.2: 18 h / 20 °C
4.1: tetrahydrofuran / 0.33 h / 0 °C
5.1: N-benzyl-trimethylammonium hydroxide / ethyl acetate / 16 h / Reflux
With
N-benzyl-trimethylammonium hydroxide; sodium carbonate; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate;
DOI:10.1002/ejoc.201200919