4 7-DIMETHOXY-1-INDANONE 97

Base Information

• Chemical Name: 4 7-DIMETHOXY-1-INDANONE 97
• CAS No.: 52428-09-8
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2914509090
• Mol file: 52428-09-8.mol

Synonyms:4 7-DIMETHOXY-1-INDANONE 97;4,7-DIMETHOXY-2,3-DIHYDRO-1H-INDEN-1-ONE;2,3-Dihydro-4,7-dimethoxy-1H-inden-1-one

Chemical Property of 4 7-DIMETHOXY-1-INDANONE 97

Chemical Property:

• Vapor Pressure: 3.79E-05mmHg at 25°C
• Melting Point: 122-125 °C(lit.)
• Refractive Index: 1.549
• Boiling Point: 352.6 ºC at 760 mmHg
• Flash Point: 158.3 ºC
• PSA: 35.53000
• Density: 1.179
• LogP: 1.83270
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,7-Dimethoxy-1-indanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,7-Dimethoxy-1-indanone acts as a reagent for the synthesis and biological evaluation of indenopyrazine dicarbonitrile as inhibitors of deubiquitinating enzymes.

Technology Process of 4 7-DIMETHOXY-1-INDANONE 97

There total 10 articles about 4 7-DIMETHOXY-1-INDANONE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(2,5-dimethoxyphenyl)propionyl chloride (100126-94-1) → 4,7-dimethoxyindan-1-one (52428-09-8)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; for 2h; Ambient temperature;

Reference yield: 72.0%

3-(2,5-dimethoxyphenyl)propanoic acid (10538-49-5) → 4,7-dimethoxyindan-1-one (52428-09-8)

Guidance literature:

3-(2,5-dimethoxyphenyl)propanoic acid; With thionyl chloride; N,N-dimethyl-formamide; for 5h; Reflux;

With aluminum (III) chloride; In dichloromethane; at -5 ℃; for 0.833333h;

DOI:10.1002/jhet.2113

Reference yield: 60.0%

N,N-Dimethylacrylamide (2680-03-7,68761-83-1) + 1,4-dimethoxybezene (150-78-7) → 4,7-dimethoxyindan-1-one (52428-09-8)

Guidance literature:

With trifluoromethanesulfonic acid anhydride; In 1,2-dichloro-ethane; for 8h; Heating;

DOI:10.1016/0040-4039(96)00794-0

upstream raw materials:

3-(2,5-dimethoxyphenyl)propanoic acid

benzene

3-(2,5-dimethoxyphenyl)propionyl chloride

N,N-Dimethylacrylamide

Downstream raw materials:

aniline

4,7-dimethoxy-3H-indene-1-carbonitrile

6'-bromo-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

6'-formyl-4,7-dimethoxy-6-(2,4,5-trichloro-3,6-dimethoxybenzyl)-2,2'-spirobiindane

Refernces

• 1、 Kotha, Sambasivarao,Cheekatla, Subba Rao,Mandal, Binita. "Synthesis and rearrangement of cage [4.3.2]propellanes that contain a spiro linkage". . p. 4277 - 4282. Retrieved 2018/08/28.
• 2、 Mejlsoe, Soren L.,Christensen, Jorn B.. "Synthesis and characterization of geminally dialkylsubstituted tetraindanotetraoxa[8]circulenes". . p. 1051 - 1057. Retrieved 2014/08/05.