D₁-(2-nitrophenyl)methanol

Base Information

• Chemical Name: D₁-(2-nitrophenyl)methanol
• CAS No.: 29809-24-3
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 154.13
• Mol file: 29809-24-3.mol

Synonyms:D₁-(2-nitrophenyl)methanol

Chemical Property of D₁-(2-nitrophenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D₁-(2-nitrophenyl)methanol

There total 2 articles about D₁-(2-nitrophenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-nitro-benzaldehyde (552-89-6) → 1,2-bis(2-nitrophenyl)ethane-1,2-diol (62635-27-2) + D1-(2-nitrophenyl)methanol (29809-24-3)

Guidance literature:

With tributylphosphine; water-d2; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.201200019

Reference yield: 69.0%

2-nitro-benzaldehyde (552-89-6) → D1-(2-nitrophenyl)methanol (29809-24-3)

Guidance literature:

With sodium borodeuteride; In ethanol; at 0 - 20 ℃;

DOI:10.1021/jacs.6b07368

Reference yield:

D1-(2-nitrophenyl)methanol (29809-24-3) → 2-azidobenzaldehyde (16714-25-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 15 h / 20 °C / Inert atmosphere

2: sodium azide / N,N,N,N,N,N-hexamethylphosphoric triamide / 48 h / 20 °C / Inert atmosphere

With sodium azide; pyridinium chlorochromate; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane;

DOI:10.1021/jacs.6b07368

upstream raw materials:

2-nitro-benzaldehyde

Downstream raw materials:

2-nitrobenzaldehyde-α-d₁

2-nitro-benzaldehyde

2-azidobenzaldehyde

o-aminobenzaldehyde

Refernces

• 1、 Wei, Yin,Liu, Xu-Guang,Shi, Min. "Reduction of activated carbonyl groups using alkylphosphanes as reducing agents: A mechanistic study". scheme or table. p. 2386 - 2393. Retrieved 2012/06/04.