(R)-2-Methylpiperazine(L)tartaricacidsalt

Base Information

• Chemical Name: (R)-2-Methylpiperazine(L)tartaricacidsalt
• CAS No.: 126458-16-0
• Molecular Formula: C9H18N2O6
• Molecular Weight: 250.252
• DSSTox Substance ID: DTXSID30704903
• Mol file: 126458-16-0.mol

Synonyms:126458-16-0;(R)-2-METHYLPIPERAZINE(L)TARTARICACIDSALT;(3R)-2,3-dihydroxybutanedioic acid;(2R)-2-methylpiperazine;DTXSID30704903;AKOS025401347;AC-11884;(2R)-2,3-Dihydroxybutanedioic acid--(2R)-2-methylpiperazine (1/1)

Chemical Property of (R)-2-Methylpiperazine(L)tartaricacidsalt

Chemical Property:

• Refractive Index: 1.417
• PSA: 139.12000
• LogP: -1.89730
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 250.11648630
• Heavy Atom Count: 17
• Complexity: 188

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-METHYL PIPERAZINE (L)TARTARIC ACID SALT 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CNCCN1.C(C(C(=O)O)O)(C(=O)O)O
• Isomeric SMILES: C[C@@H]1CNCCN1.[C@@H](C(C(=O)O)O)(C(=O)O)O

Technology Process of (R)-2-Methylpiperazine(L)tartaricacidsalt

There total 1 articles about (R)-2-Methylpiperazine(L)tartaricacidsalt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

L-Tartaric acid (87-69-4,138508-61-9) + (RS)-2-methylpiperazine (109-07-9) → (R)-2-methylpiperazine, L-tartrate (126458-16-0,126458-15-9)

Guidance literature:

In ethanol; water; at 10 - 22 ℃; for 2h;

Reference yield: 67.0%

(R)-2-methylpiperazine, L-tartrate (126458-16-0,126458-15-9) → (2R)-methylpiperazine (75336-86-6)

Guidance literature:

With sodium hydroxide; In branched octane; water; at 80 ℃; for 2h;

Reference yield:

(R)-2-methylpiperazine, L-tartrate (126458-16-0,126458-15-9) → (R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine (313657-76-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / branched octane; water / 2 h / 80 °C

2: triethylamine / dichloromethane; acetonitrile / 1.5 h / 20 - 30 °C

3: potassium carbonate / DMF (N,N-dimethyl-formamide) / 41.5 h / 127 - 133 °C

4: sulfuric acid / water; isopropyl alcohol / 0.5 h / 77 - 83 °C

With sodium hydroxide; sulfuric acid; potassium carbonate; triethylamine; In DMF (N,N-dimethyl-formamide); branched octane; dichloromethane; water; isopropyl alcohol; acetonitrile;

upstream raw materials:

L-Tartaric acid

(RS)-2-methylpiperazine

Downstream raw materials:

(2R)-methylpiperazine

(2R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine, hydrochloride

(R)-1-(3-chloro-2-pyrazinyl)-2-methylpiperazine

(3R)-3-Methyl-1-Tritylpiperazine

Refernces