3-Pyridinepropanoicacid,4-methyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinepropanoicacid,4-methyl-(9CI)
• CAS No.: 129483-51-8
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.192
• Mol file: 129483-51-8.mol

Synonyms:3-Pyridinepropanoicacid,4-methyl-(9CI)

Chemical Property of 3-Pyridinepropanoicacid,4-methyl-(9CI)

Chemical Property:

• PSA: 50.19000
• LogP: 1.40720

Purity/Quality:

99%min ^*data from raw suppliers

4-Methyl-3-PyridinepropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinepropanoicacid,4-methyl-(9CI)

There total 16 articles about 3-Pyridinepropanoicacid,4-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-methyl-pyridine (129483-54-1) → 3-(4-methyl-pyridin-3-yl)-propionic acid (129483-51-8)

Guidance literature:

With hydrogenchloride; potassium permanganate; for 16h; Ambient temperature;

DOI:10.3987/COM-89-S17

Reference yield:

3-cyano-4-methylpyridine (5444-01-9) → 3-(4-methyl-pyridin-3-yl)-propionic acid (129483-51-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) DIBAL, 2.) 1 N HCl / 1.) CH₂Cl₂/hexane, from -78 deg C, to RT, 2.) 1 h

2: 81 percent / benzene / 5 h / Ambient temperature

3: H₂ / Pd/C / ethanol / 3 h / 50 °C / 1520 Torr

4: KOH, H₂O

With hydrogenchloride; potassium hydroxide; water; hydrogen; diisobutylaluminium hydride; palladium on activated charcoal; In ethanol; benzene;

DOI:10.3987/COM-89-S17

Reference yield:

2,6-dihydroxy-3-cyano-4-methylpyrimidine (5444-02-0) → 3-(4-methyl-pyridin-3-yl)-propionic acid (129483-51-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) POCl₃, 2.) H₂, PdCl₂-AcONa / 1.) 180 deg C, 4 h, 2.) 40 deg C, 3 atm, 12 h

2: 1.) DIBAL, 2.) 1 N HCl / 1.) CH₂Cl₂/hexane, from -78 deg C, to RT, 2.) 1 h

3: 81 percent / benzene / 5 h / Ambient temperature

4: H₂ / Pd/C / ethanol / 3 h / 50 °C / 1520 Torr

5: KOH, H₂O

With hydrogenchloride; potassium hydroxide; water; hydrogen; sodium acetate; diisobutylaluminium hydride; palladium dichloride; trichlorophosphate; palladium on activated charcoal; In ethanol; benzene;

DOI:10.3987/COM-89-S17

upstream raw materials:

3-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-4-methyl-pyridine

3-(4-methyl-pyridin-3-yl)-propionic acid ethyl ester

3,4,5,6-tetrahydro-2H-pyran-2-one

3-cyano-4-methylpyridine

Downstream raw materials:

(S)-2-tert-Butoxycarbonylamino-6-[3-(4-methyl-pyridin-3-yl)-propionylamino]-hexanoic acid methyl ester

Refernces

• 1、 Maeda,Osugi. "Study on the synthesis of rac-3-methoxy-6-oxo-N-methylmorphinan.". . p. 897 - 908. Retrieved 2007/10/04.