N,N-diethyl-4-methoxy-benzamide

Base Information

• Chemical Name: N,N-diethyl-4-methoxy-benzamide
• CAS No.: 7465-86-3
• Molecular Formula: C12H17 N O2
• Molecular Weight: 207.272
• Hs Code.: 2924299090
• Mol file: 7465-86-3.mol

Synonyms:p-Anisamide,N,N-diethyl- (7CI,8CI); 4-Methoxy-N,N-diethylbenzamide;N,N-Diethyl-4-methoxybenzamide; N,N-Diethyl-p-methoxybenzamide; NSC 27695; NSC404044

Chemical Property of N,N-diethyl-4-methoxy-benzamide

Chemical Property:

• Vapor Pressure: 7.22E-05mmHg at 25°C
• Boiling Point: 343.1°C at 760 mmHg
• Flash Point: 161.3°C
• PSA: 29.54000
• Density: 1.027g/cm³
• LogP: 2.17720

Purity/Quality:

99% ^*data from raw suppliers

N,N-DIETHYL-4-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Used to synthesis selective mono-fluorination of 1,2- and 1,3-diols.

Technology Process of N,N-diethyl-4-methoxy-benzamide

There total 47 articles about N,N-diethyl-4-methoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chloro-N,N-diethyl-benzamide (7461-38-3) + C4H12BO4(1+)*K(1+) → 4-methoxy-N,N-diethylbenzamide (7465-86-3)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In N,N-dimethyl-formamide; at 100 ℃; Inert atmosphere;

DOI:10.1002/adsc.201300687

Reference yield: 94.0%

4-methoxybenzoic acid (100-09-4) + diethylamine (109-89-7) → 4-methoxy-N,N-diethylbenzamide (7465-86-3)

Guidance literature:

With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; for 4h;

Reference yield: 94.0%

carbon monoxide (201230-82-2) + para-iodoanisole (696-62-8) + triethylamine (121-44-8) → 4-methoxy-N,N-diethylbenzamide (7465-86-3)

Guidance literature:

With palladium 10% on activated carbon; oxygen; In acetonitrile; at 100 ℃; for 8h; under 4560.31 Torr; Autoclave; Green chemistry;

DOI:10.1021/acs.joc.5b02385

upstream raw materials:

4-methoxy-benzoyl chloride

diethylamine

N, N-diethyl-4-hydroxybenzamide

dimethyl sulfate

Downstream raw materials:

diethyl-[1-ethyl-1-(4-methoxy-phenyl)-propyl]-amine

4-Methoxypropiophenone

diethyl[(4-methoxyphenyl)diphenylmethyl]amine

5-methoxy-7-methyl-3-(3',5'-dimethoxyphenyl)phthalide

Refernces

• 1、 Kolekar, Yuvraj A.,Bhanage, Bhalchandra M.. "Pd-Catalyzed Oxidative Aminocarbonylation of Arylboronic Acids with Unreactive Tertiary Amines via C-N Bond Activation". . p. 14028 - 14035. Retrieved 2021/05/29.
• 2、 Qi, Xinxin,Zhou, Rong,Ai, Han-Jun,Wu, Xiao-Feng. "HMF and furfural: Promising platform molecules in rhodium-catalyzed carbonylation reactions for the synthesis of furfuryl esters and tertiary amides". . p. 215 - 221. Retrieved 2019/11/25.