Benzaldehyde, 4-amino-3,5-difluoro- (9CI)

Base Information

• Chemical Name: Benzaldehyde, 4-amino-3,5-difluoro- (9CI)
• CAS No.: 135564-23-7
• Molecular Formula: C7H5F2NO
• Molecular Weight: 157.12
• Mol file: 135564-23-7.mol

Synonyms:Benzaldehyde, 4-amino-3,5-difluoro- (9CI)

Chemical Property of Benzaldehyde, 4-amino-3,5-difluoro- (9CI)

Chemical Property:

• Boiling Point: 235.0±40.0 °C(Predicted)
• PKA: -0.92±0.10(Predicted)
• PSA: 43.09000
• Density: 1.405±0.06 g/cm3(Predicted)
• LogP: 1.94070

Purity/Quality:

99%, ^*data from raw suppliers

4-amino-3,5-difluorobenzaldehyde 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzaldehyde, 4-amino-3,5-difluoro- (9CI)

There total 1 articles about Benzaldehyde, 4-amino-3,5-difluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-amino-3,5-difluorobenzonitrile (110301-23-0) → 4-amino-3,5-difluorobenzaldehyde (135564-23-7)

Guidance literature:

4-amino-3,5-difluorobenzonitrile; With diisobutylaluminium hydride; In toluene; at 0 - 20 ℃; for 2h;

With water; citric acid; In toluene;

Reference yield:

cyclopentyl leucinate (205180-05-8) + 4-amino-3,5-difluorobenzaldehyde (135564-23-7) → cyclopentyl 2(S)-[(4-amino-3,5-difluorobenzyl)amino]-4-methylpentanoate (956926-71-9)

Guidance literature:

cyclopentyl leucinate; 4-amino-3,5-difluorobenzaldehyde; With potassium carbonate; acetic acid; In methanol; N,N-dimethyl-formamide; for 1h; pH=5 - 6;

With sodium cyanoborohydride; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

cyclopentyl leucinate (205180-05-8) + 4-amino-3,5-difluorobenzaldehyde (135564-23-7) → cyclopentyl (S)-2-[(4-amino-3,5-difluorobenzyl)-tert-butoxycarbonylamino]-4-methylpentanoate (956926-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; acetic acid / methanol; N,N-dimethyl-formamide / 1 h / pH 5 - 6

1.2: 18 h / 20 °C

2.1: potassium carbonate / tetrahydrofuran; water / 18 h / 20 °C

With potassium carbonate; acetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

4-amino-3,5-difluorobenzonitrile

Downstream raw materials:

cyclopentyl 2(S)-[(4-amino-3,5-difluorobenzyl)amino]-4-methylpentanoate

cyclopentyl (S)-2-[(4-amino-3,5-difluorobenzyl)-tert-butoxycarbonylamino]-4-methylpentanoate

Refernces