4-Decyl-2,3-difluorobenzeneboronic acid

Base Information

• Chemical Name: 4-Decyl-2,3-difluorobenzeneboronic acid
• CAS No.: 147223-09-4
• Molecular Formula: C16H25 B F2 O2
• Molecular Weight: 298.18
• Mol file: 147223-09-4.mol

Synonyms:4-Decyl-2,3-difluorobenzeneboronic acid

Chemical Property of 4-Decyl-2,3-difluorobenzeneboronic acid

Chemical Property:

• PSA: 40.46000
• LogP: 3.32780

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Decyl-2,3-difluorobenzeneboronic acid

There total 6 articles about 4-Decyl-2,3-difluorobenzeneboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

caprinaldehyde (112-31-2) → 4-n-Decyl-2,3-difluorophenyl boronic acid (147223-09-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

1.2: hexane; tetrahydrofuran / -78 - 20 °C

2.1: P₂O₅ / light petroleum / 20 °C

3.1: H₂ / 5 percent Pd/C / light petroleum / 12 h / 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

4.2: hexane; tetrahydrofuran / -78 - 20 °C

5.1: 10 percent aq. HCl / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; phosphorus pentoxide; palladium on activated charcoal; In tetrahydrofuran; hexane; Petroleum ether; 1.1: Metallation / 1.2: Addition / 2.1: Dehydration / 3.1: Hydrogenation / 4.1: Metallation / 4.2: Substitution / 5.1: Hydrolysis;

DOI:10.1039/a902351h

Reference yield:

ortho-difluorobenzene (367-11-3) → 4-n-Decyl-2,3-difluorophenyl boronic acid (147223-09-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 3 h / -78 °C

1.2: hexane; tetrahydrofuran / -78 - 20 °C

2.1: P₂O₅ / light petroleum / 20 °C

3.1: H₂ / 5 percent Pd/C / light petroleum / 12 h / 20 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

4.2: hexane; tetrahydrofuran / -78 - 20 °C

5.1: 10 percent aq. HCl / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; phosphorus pentoxide; palladium on activated charcoal; In tetrahydrofuran; hexane; Petroleum ether; 1.1: Metallation / 1.2: Addition / 2.1: Dehydration / 3.1: Hydrogenation / 4.1: Metallation / 4.2: Substitution / 5.1: Hydrolysis;

DOI:10.1039/a902351h

Reference yield:

1-((E)-Dec-1-enyl)-2,3-difluoro-benzene (147223-08-3) → 4-n-Decyl-2,3-difluorophenyl boronic acid (147223-09-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: H₂ / 5 percent Pd/C / light petroleum / 12 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -78 °C

2.2: hexane; tetrahydrofuran / -78 - 20 °C

3.1: 10 percent aq. HCl / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; palladium on activated charcoal; In tetrahydrofuran; hexane; Petroleum ether; 1.1: Hydrogenation / 2.1: Metallation / 2.2: Substitution / 3.1: Hydrolysis;

DOI:10.1039/a902351h

upstream raw materials:

caprinaldehyde

ortho-difluorobenzene

1-((E)-Dec-1-enyl)-2,3-difluoro-benzene

1-n-decyl-2,3-difluorobenzene

Refernces

• 1、 -. "Dioxane derivatives". . . Retrieved 2008/06/13.