phenyl 2-bromopropanoate

Base Information

• Chemical Name: phenyl 2-bromopropanoate
• CAS No.: 42710-26-9
• Molecular Formula: C9H9 Br O2
• Molecular Weight: 229.073
• Mol file: 42710-26-9.mol

Synonyms:NSC 64456;Phenyl 2-bromopropionate

Chemical Property of phenyl 2-bromopropanoate

Chemical Property:

• Vapor Pressure: 0.00682mmHg at 25°C
• Boiling Point: 270.5°C at 760 mmHg
• Flash Point: 117.4°C
• Density: 1.457g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl 2-bromopropanoate

There total 5 articles about phenyl 2-bromopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

α-bromopropionyl bromide (563-76-8) + phenol (108-95-2,27073-41-2) → phenyl 2-bromopropionate (42710-26-9)

Guidance literature:

phenol; With pyridine; In acetonitrile; at 0 ℃;

α-bromopropionyl bromide; In acetonitrile; at 0 ℃; for 0.5h;

DOI:10.1021/ol202977j

Reference yield: 84.0%

2-Bromopropionic acid (598-72-1,10327-08-9) + phenol (108-95-2,27073-41-2) → phenyl 2-bromopropionate (42710-26-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In diethyl ether; at 20 ℃; for 1.5h;

DOI:10.1021/ol990971n

Reference yield: 73.0%

2-Bromopropionic acid (598-72-1,10327-08-9) + Phenyl[2-(trimethylsilyl)phenyl]iodonium trifluoromethanesulfonate (164594-13-2) → phenyl 2-bromopropionate (42710-26-9)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1080/00397910701397417

upstream raw materials:

sodium phenoxide

benzene

α-bromopropionyl bromide

phenol

Downstream raw materials:

2-phenoxy-propionic acid phenyl ester

2-methyl-benzofuran-3-ol

phenyl 2-nitropropanoate

2-(4-Chloro-phenoxy)-propionic acid phenyl ester

Refernces

• 1、 Osako, Takao,Panichakul, Duanghathai,Uozumi, Yasuhiro. "Enantioselective carbenoid insertion into phenolic O-H bonds with a chiral copper(I) imidazoindolephosphine complex". supporting information; experimental part. p. 194 - 197. Retrieved 2012/02/16.
• 2、 Kihara, Nobuhiro,Ollivier, Cyril,Renaud, Philippe. "Efficient radical oxygenation of α-lodocarboxylic acid derivatives". . p. 1419 - 1422. Retrieved 2008/02/09.