3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE

Base Information

• Chemical Name: 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE
• CAS No.: 150114-69-5
• Molecular Formula: C11H12 O5
• Molecular Weight: 224.213
• Mol file: 150114-69-5.mol

Synonyms:3,4,5-Trimethoxyphenylglyoxal;NSC 142535

Chemical Property of 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE

Chemical Property:

• Vapor Pressure: 5.63E-08mmHg at 25°C
• Melting Point: 128-131°C
• Refractive Index: ">
• Boiling Point: 424.8°Cat760mmHg
• Flash Point: 210.7°C
• PSA: 85.22000
• Density: g/cm³
• LogP: 0.20580

Purity/Quality:

98%min ^*data from raw suppliers

2-Oxo-2-(3,4,5-trimethoxyphenyl)acetaldehydehydrate 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

Technology Process of 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE

There total 5 articles about 3,4,5-TRIMETHOXYPHENYLGLYOXAL HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) → 2-oxo-2-(3,4,5-trimethoxyphenyl)acetaldehyde (150114-69-5)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; for 3h; Reflux;

DOI:10.1016/j.bmc.2017.10.045

Reference yield:

2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanol (1374568-07-6) → 2-oxo-2-(3,4,5-trimethoxyphenyl)acetaldehyde (150114-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 19 h / 20 °C

2: dimethyl sulfoxide / 60 h / 40 °C

With dimethyl sulfoxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide;

DOI:10.1002/ejoc.201101835

Reference yield:

2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone (1374568-30-5) → 2-oxo-2-(3,4,5-trimethoxyphenyl)acetaldehyde (150114-69-5)

Guidance literature:

With dimethyl sulfoxide; at 40 ℃; for 60h;

DOI:10.1002/ejoc.201101835

upstream raw materials:

2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanol

2,2-diiodo-1-(3,4,5-trimethoxyphenyl)ethanone

3,4,5-trimethoxy-benzaldehyde

methyl (3,4,5-trimethoxyphenyl) ketone

Downstream raw materials:

2-(3,4,5-trimethoxyphenyl)benzopyrazine

Refernces

• 1、 El-Mahdy, Ahmed F. M.,Shibata, Takayuki,Kabashima, Tsutomu,Kai, Masaaki. "Dendrimer-like polymeric DNAs as chemiluminescence probes for amplified detection of telomere DNA on a solid-phase membrane". supporting information. p. 859 - 861. Retrieved 2014/01/06.
• 2、 Zall, Andrea,Bensinger, Dennis,Schmidt, Boris. "Oxidative homologation of aldehydes to α-ketoaldehydes by using iodoform, o-iodoxybenzoic acid, and dimethyl sulfoxide". . p. 1439 - 1447. Retrieved 2012/04/04.