2,3,6-TRIMETHOXYBENZOIC ACID

Base Information

• Chemical Name: 2,3,6-TRIMETHOXYBENZOIC ACID
• CAS No.: 60241-74-9
• Molecular Formula: C10H12O5
• Molecular Weight: 212.202
• Hs Code.: 2918990090
• Mol file: 60241-74-9.mol

Synonyms:2,3,6-TRIMETHOXYBENZOIC ACID;Trimethoxybenzoicacid;2,3,6-TRIMETHOXYBENZOIC ACIDB

Chemical Property of 2,3,6-TRIMETHOXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 2.49E-05mmHg at 25°C
• Melting Point: 150°C
• Refractive Index: 1.523
• Boiling Point: 344.5oC at 760 mmHg
• PKA: 3.86±0.10(Predicted)
• Flash Point: 134.6oC
• PSA: 64.99000
• Density: 1.219g/cm3
• LogP: 1.41060
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,3,6-Trimethoxybenzoic Acid >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3,6-TRIMETHOXYBENZOIC ACID

There total 8 articles about 2,3,6-TRIMETHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.5%

methyl 2,3,6-trimethoxybenzoate (60241-75-0) → 2,3,6-trimethoxybenzoic acid (60241-74-9)

Guidance literature:

With sodium hydroxide; In methanol; water; at 90 ℃; for 4h;

Reference yield:

2,3-dimethoxy-6-nitrobenzoic acid (72517-26-1) → 2,3,6-trimethoxybenzoic acid (60241-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: iron (II)-sulfate; aqueous ammonia / Versetzen des Reaktionsgemisches mit ueberschuessiger wss. Salzsaeure und Natriumnitrit

2: aqueous KOH-solution

With potassium hydroxide; ammonium hydroxide; iron(II) sulfate;

DOI:10.1021/ja01359a033

Reference yield:

1,2,4-trimethoxy-benzene (135-77-3) + methylammonium carbonate (15719-64-9,15719-76-3,97762-63-5) → 2,3,6-trimethoxybenzoic acid (60241-74-9)

Guidance literature:

With n-butyllithium;

DOI:10.1021/ja01234a002

upstream raw materials:

1,2,4-trimethoxy-benzene

methylammonium carbonate

2,3,6-trimethoxytoluene

2,3,6-trihydroxybenzoic acid

Downstream raw materials:

1,3-dihydroxy-7,8-dimethoxyxanthone

1,3-dihydroxy-5,8-dimethoxyxanthone

norswertianin

1,3,5,8-tetrahydroxyxanthone

Refernces

• 1、 Foetsch, G.,Gruendemann, E.,Pfeifer, S.,Hiller, K.,Salzwedel, D.. "Structure of leiocarposide". . p. 278 - 280. Retrieved 2007/10/02.