4-fluoro-N-hydroxybenzamide

Base Information

• Chemical Name: 4-fluoro-N-hydroxybenzamide
• CAS No.: 456-07-5
• Molecular Formula: C7H6 F N O2
• Molecular Weight: 155.129
• Mol file: 456-07-5.mol

Synonyms:Benzohydroxamicacid, p-fluoro- (6CI,7CI,8CI); 4-Fluoro-N-hydroxybenzamide;4-Fluorobenzohydroxamic acid; 4-Fluorobenzoylhydroxamic acid; NSC 111683;p-Fluorobenzohydroxamic acid

Chemical Property of 4-fluoro-N-hydroxybenzamide

Chemical Property:

• Melting Point: 161-162 °C(Solv: acetone (67-64-1); ethyl ether (60-29-7))
• PKA: 8.76±0.10(Predicted)
• PSA: 49.33000
• Density: 1.349g/cm³
• LogP: 1.33560

Purity/Quality:

98%min ^*data from raw suppliers

4-FLUORO-N-HYDROXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-fluoro-N-hydroxybenzamide

There total 7 articles about 4-fluoro-N-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-fluorobenzoyl chloride (403-43-0) → 4-fluorobenzohydroxamic acid (456-07-5)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 16h;

DOI:10.1039/c8ob00490k

Reference yield: 92.0%

4-fluorobenzylic alcohol (459-56-3) → 4-fluorobenzohydroxamic acid (456-07-5)

Guidance literature:

4-fluorobenzylic alcohol; With 1-hydroxy-pyrrolidine-2,5-dione; [bis(acetoxy)iodo]benzene; In acetonitrile; at 0 - 20 ℃; for 3h; Inert atmosphere; Green chemistry;

With hydroxylamine; In water; acetonitrile; for 12h; Inert atmosphere; Green chemistry;

DOI:10.1039/c4ob00693c

Reference yield: 83.0%

4-Fluorobenzoic acid (456-22-4) → 4-fluorobenzohydroxamic acid (456-07-5)

Guidance literature:

4-Fluorobenzoic acid; With 4-[(2,4-(MeO)2-benzyl)-ONHCH₂]-3-MeO-phenoxy-Merrified resin; dacarbazine; dmap; In N,N-dimethyl-formamide; at 20 ℃;

With trifluoroacetic acid; In dichloromethane;

DOI:10.1080/00397910500278115

upstream raw materials:

4-fluorobenzoic acid ethyl ester

4-fluorobenzoyl chloride

4-Fluorobenzoic acid

1-(p-fluorophenylcarbonyl)imidazole

Downstream raw materials:

O-tert-butyldimethylsilyl-p-fluorobenzohydroxamic acid

N-(4-fluorophenyl)formamide

N-tert-pentanoyloxy-p-fluorobenzamide

2-(4-fluorophenyl)-4H-benzo[d][1,3]oxazin-4-one

Refernces

• 1、 Yu, Yongqi,Xia, Zhen,Wu, Qianlong,Liu, Da,Yu, Lin,Xiao, Yuanjiu,Tan, Ze,Deng, Wei,Zhu, Gangguo. "Direct synthesis of benzoxazinones via Cp*Co(III)-catalyzed C–H activation and annulation of sulfoxonium ylides with dioxazolones". supporting information. p. 1263 - 1266. Retrieved 2020/10/08.
• 2、 Zhang, Xinyu,Lin, Bo,Chen, Jianhui,Chen, Jiajia,Luo, Yanshu,Xia, Yuanzhi. "Synthesis of sulfimides and N-Allyl-N-(thio)amides by Ru(II)catalyzed nitrene transfer reactions of N-acyloxyamides". supporting information. p. 819 - 825. Retrieved 2021/02/01.