(R)-3-(P-Methylphenyl)-beta-alanine

Base Information

• Chemical Name: (R)-3-(P-Methylphenyl)-beta-alanine
• CAS No.: 479064-87-4
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2922499990
• Mol file: 479064-87-4.mol

Synonyms:H-D-b-Phe(4-Me)-OH;(R)-3-Amino-(4-tolyl)propionicacid;

Chemical Property of (R)-3-(P-Methylphenyl)-beta-alanine

Chemical Property:

• Refractive Index: 1.567
• Boiling Point: 325.5 °C at 760 mmHg
• Flash Point: 150.7 °C
• PSA: 63.32000
• Density: 1.163 g/cm³
• LogP: 2.16980
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-(p-Methylphenyl)-β-alanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-(P-Methylphenyl)-beta-alanine

There total 10 articles about (R)-3-(P-Methylphenyl)-beta-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methylcinnamic acid (1866-39-3,940-61-4) → (R)-3-amino-3-(4-methyl-phenyl)-propionic acid (479064-87-4,479065-00-4)

Guidance literature:

With ammonia; at 25 ℃; pH=9; regioselective reaction; Kinetics; aq. buffer; Enzymatic reaction;

DOI:10.1002/anie.201106372

Reference yield: 42.0%

(+/-)-4-(p-tolyl)-2-azetidinone (21161-19-3) → (S)-4-(p-tolyl)-2-azetidinone (402828-03-9) + (R)-4-(p-tolyl)-2-azetidinone + (R)-3-amino-3-(4-methyl-phenyl)-propionic acid (479064-87-4,479065-00-4)

Guidance literature:

With CAL-B (lipase B from Candida antarctica); water; In isopropyl alcohol; at 60 ℃; for 30h;

DOI:10.1002/adsc.200505434

Reference yield: 7.0%

(+/-)-4-(p-tolyl)-2-azetidinone (21161-19-3) → (S)-4-(p-tolyl)-2-azetidinone (402828-03-9) + (R)-3-amino-3-(4-methyl-phenyl)-propionic acid (479064-87-4,479065-00-4)

Guidance literature:

With lipase B from Candida antarctica (Novozym 435, CAL-B); In di-isopropyl ether; at 60 ℃; for 48h;

DOI:10.1002/adsc.200303069

upstream raw materials:

(+/-)-4-(p-tolyl)-2-azetidinone

4-methyl-L-phenylalanine

p-methylphenylalanine

trans-p-methylcinnamic acid

Refernces

• 1、 Wu, Bian,Szymanski, Wiktor,Wybenga, Gjalt G.,Heberling, Matthew M.,Bartsch, Sebastian,Dewildeman, Stefaan,Poelarends, Gerrit J.,Feringa, Ben L.,Dijkstra, Bauke W.,Janssen, Dick B.. "Mechanism-inspired engineering of phenylalanine aminomutase for enhanced β-regioselective asymmetric amination of cinnamates". supporting information; experimental part. p. 482 - 486. Retrieved 2012/03/22.
• 2、 Cox, Brad M.,Bilsborrow, Joshua B.,Walker, Kevin D.. "Enhanced conversion of racemic α-arylalanines to (R)-β- arylalanines by coupled racemase/aminomutase catalysis". experimental part. p. 6953 - 6959. Retrieved 2009/12/25.