2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE

Base Information

• Chemical Name: 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE
• CAS No.: 56798-34-6
• Molecular Formula: C17H16O5
• Molecular Weight: 300.31
• Mol file: 56798-34-6.mol

Synonyms:Flavokawain C;ZINC04100761;

Chemical Property of 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE

Chemical Property:

• Melting Point: 194-196°C
• Refractive Index: 1.636
• Boiling Point: 556 °C at 760 mmHg
• Flash Point: 207.2 °C
• PSA: 75.99000
• Density: 1.279 g/cm³
• LogP: 3.01110

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE

There total 6 articles about 2',4-DIHYDROXY-4',6'-DIMETHOXYCHALCONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4',6'-dimethoxy-2',4-dihydroxychalcone (56798-34-6)

Guidance literature:

With sodium hydroxide; water; In ethanol; several hours;

DOI:10.1002/jps.2600840416

Reference yield: 35.0%

→ 4',6'-dimethoxy-2',4-dihydroxychalcone (56798-34-6)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 20h;

Reference yield:

2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone (77184-69-1) → 4',6'-dimethoxy-2',4-dihydroxychalcone (56798-34-6)

Guidance literature:

With hydrogenchloride; In ethanol; at 70 ℃; for 0.25h;

DOI:10.1021/acs.molpharmaceut.8b00288

upstream raw materials:

2-hydroxy-4,6-dimethoxyacetophenone

4-hydroxy-benzaldehyde

2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone

4-methoxymethoxy-benzaldehyde

Downstream raw materials:

4-(5,7-dimethoxy-4-oxochroman-2-yl)phenyl phenylcarbamate

2-(4-hydroxyphenyl)-5,7-dimethoxychroman-4-one

Refernces

• 1、 Choi, Daheui,Park, Jin Chan,Lee, Ha Na,Moon, Ji-Hoi,Ahn, Hyo-Won,Park, Kwangyong,Hong, Jinkee. "In Vitro Osteogenic Differentiation and Antibacterial Potentials of Chalcone Derivatives". . p. 3197 - 3204. Retrieved 2018/07/25.
• 2、 Anand, Preet,Singh, Baldev. "Synthesis and evaluation of novel carbamate-substituted flavanone derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents". . p. 1648 - 1659. Retrieved 2013/07/26.