(4-(Methylsulfonyl)phenyl)hydrazine hydrochloride

Base Information

• Chemical Name: (4-(Methylsulfonyl)phenyl)hydrazine hydrochloride
• CAS No.: 17852-67-4
• Molecular Formula: C7H10N2O2S^.HCl
• Molecular Weight: 222.696
• Hs Code.: 29280000
• European Community (EC) Number: 674-172-6
• Mol file: 17852-67-4.mol

Synonyms:17852-67-4;(4-(Methylsulfonyl)phenyl)hydrazine hydrochloride;4-(Methylsulfonyl)phenylhydrazine hydrochloride;[4-(Methylsulfonyl)phenyl]hydrazine hydrochloride;4-(methylsulphonyl)phenylhydrazine hydrochloride;4-methylsulphonylphenylhydrazine hydrochloride;(4-methanesulfonylphenyl)hydrazine hydrochloride;4-methylsulfonylphenylhydrazine hydrochloride;4-(METHYLSULFONYL)PHENYLHYDRAZINE, HCL;MFCD00216494;Hydrazine, [4-(methylsulfonyl)phenyl]-, monohydrochloride;MFCD00007580;(4-methylsulfonylphenyl)hydrazine Hydrochloride;SCHEMBL839104;QVCMFSJTNVQJFG-UHFFFAOYSA-N;4-(Methylsulfonyl)phenylhydrazine HCl;AKOS015849368;CS-W006198;DS-15938;SY018879;AM20060926;FT-0717330;4-methylsulfonyl-phenylhydrazine hydrochloride;(4-methanesulfonyl)phenylhydrazine hydrochloride;(4-methylsulfonylphenyl)hydrazine;hydrochloride;(4-(Methylsulfonyl)phenyl)hydrazinehydrochloride;EN300-7358472;A812378;1-(4-methanesulfonyl-phenyl)-hydrazine hydrochloride;1-(4-methanesulfonyl-phenyl)- hydrazine hydrochloride;[4-(Methylsulfonyl)phenyl]hydrazine hydrochloride (1:1);Hydrazine, [4-(methylsulfonyl)phenyl]-, hydrochloride (1:1)

Chemical Property of (4-(Methylsulfonyl)phenyl)hydrazine hydrochloride

Chemical Property:

• Appearance/Colour: off-white to light yellow crystalline powder
• Vapor Pressure: 3.22E-07mmHg at 25°C
• Melting Point: 202 °C
• Boiling Point: 418.7 °C at 760 mmHg
• Flash Point: 207 °C
• PSA: 80.57000
• LogP: 3.03180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: SOLUBLE
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 222.0229765
• Heavy Atom Count: 13
• Complexity: 224

Purity/Quality:

99% ^*data from raw suppliers

(4-(Methylsulfonyl)phenyl)hydrazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=O)(=O)C1=CC=C(C=C1)NN.Cl

Technology Process of (4-(Methylsulfonyl)phenyl)hydrazine hydrochloride

There total 2 articles about (4-(Methylsulfonyl)phenyl)hydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.9%

4-methanesulfonylphenylamine (5470-49-5) → 4-(methylsulfonyl)phenylhydrazine hydrochloride (17852-67-4)

Guidance literature:

4-methanesulfonylphenylamine; With hydrogenchloride; sodium nitrite; In water; at -10 ℃; for 1h;

With hydrogenchloride; tin(II) chloride dihdyrate; In water; at -10 ℃; for 1h;

Reference yield:

4-bromoohenyl methyl sulfone (3466-32-8) → 4-(methylsulfonyl)phenylhydrazine hydrochloride (17852-67-4)

Guidance literature:

4-bromoohenyl methyl sulfone; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 100.0%

4-piperidone hydrochloride (41979-39-9) + 4-(methylsulfonyl)phenylhydrazine hydrochloride (17852-67-4) → 8-methylsulfonyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride

Guidance literature:

4-piperidone hydrochloride; 4-(methylsulfonyl)phenylhydrazine hydrochloride; In ethanol; at 20 ℃; for 0.5h;

With boron trifluoride diethyl etherate; acetic acid; at 90 ℃; for 16h;

upstream raw materials:

4-methanesulfonylphenylamine

4-bromoohenyl methyl sulfone

Downstream raw materials:

5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-3-carboxylic acid ethyl ester

1-(4-methanesulfonylphenyl)-5-phenyl-1H-pyrazole-3-carboxylic acid ethyl ester

5-(4-fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-1H-pyrazole-4-carboxylic acid ethyl ester

Refernces

• 1、 Kumar, Siripuram Vijay,Ma, Dawei. "Synthesis of Aryl Hydrazines via CuI/BMPO Catalyzed Cross-Coupling of Aryl Halides with Hydrazine Hydrate in Water". supporting information. p. 1003 - 1006. Retrieved 2018/09/20.