2-Amino-6-chlorobenzotrifluoride

Base Information

• Chemical Name: 2-Amino-6-chlorobenzotrifluoride
• CAS No.: 432-21-3
• Molecular Formula: C7H5ClF3N
• Molecular Weight: 195.572
• Hs Code.: 2921420090
• Mol file: 432-21-3.mol

Synonyms:o-Toluidine,3-chloro-a,a,a-trifluoro- (8CI);(3-Chloro-2-trifluoromethylphenyl)amine;2-Trifluoromethyl-3-chloroaniline;2-Chloro-6-aminobenzotrifluoride;3-Chloro-2-(trifluoromethyl)aniline;

Chemical Property of 2-Amino-6-chlorobenzotrifluoride

Chemical Property:

• Vapor Pressure: 0.0428mmHg at 25°C
• Refractive Index: 1.5
• Boiling Point: 238.2 °C at 760 mmHg
• PKA: 0.41±0.10(Predicted)
• Flash Point: 97.9 °C
• PSA: 26.02000
• Density: 1.425 g/cm³
• LogP: 3.52220
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-6-chlorobenzotrifluoride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-6-chlorobenzotrifluoride

There total 2 articles about 2-Amino-6-chlorobenzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-chloro-3-nitro-2-(trifluoromethyl)nicotinate (133391-58-9) → 3-chloro-2-(trifluoromethyl)aniline (432-21-3)

Guidance literature:

With methanol; ethanol; water; isopropyl alcohol; calcium chloride; zinc; Heating / reflux;

Reference yield: 12.0%

Bromotrifluoromethane (75-63-8) + 3-chloro-aniline (108-42-9) → 5-chloro-2-(trifluoromethyl)aniline (445-14-7) + 3-chloro-4-(trifluoromethyl)aniline (445-13-6) + 3-chloro-2-(trifluoromethyl)aniline (432-21-3)

Guidance literature:

With α-picoline; sodium metabisulfite; sulfur dioxide; zinc; In N,N-dimethyl-formamide; at 65 ℃; for 3h; under 2250.2 - 3750.3 Torr;

Reference yield: 79.0%

3-chloro-2-(trifluoromethyl)aniline (432-21-3) → 1-chloro-3-iodo-2-trifluoromethyl-benzene (1007455-52-8)

Guidance literature:

3-chloro-2-(trifluoromethyl)aniline; With hydrogenchloride; In water; at 45 ℃; for 0.5h;

With sodium nitrite; In dichloromethane; water; at 5 ℃; for 0.5h;

With sodium iodide; In dichloromethane; water; at 5 ℃; for 1h;

upstream raw materials:

Bromotrifluoromethane

3-chloro-aniline

1-chloro-3-nitro-2-(trifluoromethyl)nicotinate

Downstream raw materials:

1-chloro-3-iodo-2-trifluoromethyl-benzene

Refernces

• 1、 Tordeux, Marc,Langlois, Bernard,Wakselman, Claude. "Reactions of Trifluoromethyl Bromide and Related Halides: Part 10. Perfluoroalkylation of Aromatic Compounds induced by Sulphur Dioxide Radical Anion Precursors". . p. 2293 - 2299. Retrieved 2007/10/02.