1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97

Base Information

• Chemical Name: 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97
• CAS No.: 5554-54-1
• Molecular Formula: C10H19NO
• Molecular Weight: 169.267
• Hs Code.: 2933399090
• Mol file: 5554-54-1.mol

Synonyms:1,2,2,6,6-Pentamethylpiperidin-4-one;

Chemical Property of 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97

Chemical Property:

• Vapor Pressure: 0.128mmHg at 25°C
• Refractive Index: n20/D 1.476(lit.)
• Boiling Point: 218.1 °C at 760 mmHg
• Flash Point: 79.6 °C
• PSA: 20.31000
• Density: 0.886 g/cm³
• LogP: 1.77620
• Storage Temp.: ?20°C

Purity/Quality:

99% ^*data from raw suppliers

1,2,2,6,6-Pentamethyl-4-piperidone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1,2,2,6,6-Pentamethyl-4-piperidone may be used in the preparation of 1-phenyl-2,2,6,6-tetramethyl-4-phenyliminopiperidine and 1-benzyl-2,2,6,6-tetramethyl-4-benzyliminopiperidine.

Technology Process of 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97

There total 10 articles about 1 2 2 6 6-PENTAMETHYL-4-PIPERIDONE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,2,6,6-Tetramethyl-4-piperidone (826-36-8) + dimethyl sulfate (77-78-1) → 1,2,2,6,6-pentamethyl-4-piperidone (5554-54-1)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl acetamide; at 45 ℃; for 10h; Temperature; Solvent;

Reference yield: 95.0%

1,2,2,6,6-pentamethyl-piperidin-4-ol (2403-89-6) → 1,2,2,6,6-pentamethyl-4-piperidone (5554-54-1)

Guidance literature:

With di-μ-chlorotetrakys-[(RP)-tert-butylphenylphosphinito-κ-P]diplatinate(2-); methyl vinyl ketone; sodium hydroxide; In water; toluene; for 16h; Schlenk technique; Inert atmosphere; Heating;

DOI:10.1002/ejoc.201801040

Reference yield: 91.0%

2,2,6,6-Tetramethyl-4-piperidone (826-36-8) + carbonic acid dimethyl ester (616-38-6) → 1,2,2,6,6-pentamethyl-4-piperidone (5554-54-1)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In N,N-dimethyl-formamide; at 110 ℃; for 3h; Reagent/catalyst; Temperature; Solvent;

upstream raw materials:

2,2,6,6-Tetramethyl-4-piperidone

methyl iodide

phorone

methylamine

Downstream raw materials:

1,2,2,6,6-pentamethyl-4-phenyl-piperidin-4-ol

3,5-dimethylidene-1,2,2,6,6-pentamethyl-4-oxopiperidine

1,2,2,6,6-pentamethyl-3-methylene-4-piperidone

1,2,2,4,6,6-hexamethyl-4-piperidinol

Refernces

• 1、 -. "Green synthesis method of 1,2,2,6,6-pentamethyl-4-piperidone". Paragraph 0023. . Retrieved 2020/05/30.
• 2、 -. "Bi-radical compound composed of triaryl methyl radical and nitroxide radical and salt thereof and preparation method and application of bi-radical compound composed of triaryl methyl radical and nitroxide radical and salt thereof". Paragraph 0012; 0116; 0117; 0118. . Retrieved 2018/12/02.