(3S,4R)-3-METHYL-4-N-PHENYLAMINO-PIPERIDINE

Base Information

• Chemical Name: (3S,4R)-3-METHYL-4-N-PHENYLAMINO-PIPERIDINE
• CAS No.: 53757-51-0
• Molecular Formula: C12H18N2
• Molecular Weight: 190.28
• Hs Code.: 2933399090
• Mol file: 53757-51-0.mol

Synonyms:(3S,4R)-3-METHYL-4-N-PHENYLAMINO-PIPERIDINE

Chemical Property of (3S,4R)-3-METHYL-4-N-PHENYLAMINO-PIPERIDINE

Chemical Property:

• PSA: 24.06000
• LogP: 2.49830

Purity/Quality:

99%min ^*data from raw suppliers

(3S,4R)-3-METHYL-4-N-PHENYLAMINO-PIPERIDINE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3S,4R)-3-METHYL-4-N-PHENYLAMINO-PIPERIDINE

There total 5 articles about (3S,4R)-3-METHYL-4-N-PHENYLAMINO-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-3-methyl-N-phenyl-4-piperidinamine (58329-00-3) → (3S,4R)-(-)-cis-3-methyl-N-phenyl-4-piperidinamine (53757-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 g / H₂ / 10percent Pd/C / ethanol / 6 h / 60 °C / 775.7 Torr

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00018a026

Reference yield:

1-Benzyl-3-methyl-4-piperidon (34737-89-8) → (3S,4R)-(-)-cis-3-methyl-N-phenyl-4-piperidinamine (53757-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 2.) NaBH₄ / 1.) toluene, EtOH, 2.) toluene, EtOH

2: HCl, H₂ / Pd(OH)2/C / methanol / 120 h / 2068.6 Torr

With hydrogenchloride; sodium tetrahydroborate; hydrogen; palladium dihydroxide; In methanol;

DOI:10.1021/jm00009a015

Reference yield:

(+/-)-cis-1-benzyl-3-methyl-N-phenylpiperidinamine (58329-00-3,79278-34-5,97220-05-8,130149-82-5,130149-85-8) → (3S,4R)-(-)-cis-3-methyl-N-phenyl-4-piperidinamine (53757-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl, H₂ / Pd(OH)2/C / methanol / 120 h / 2068.6 Torr

With hydrogenchloride; hydrogen; palladium dihydroxide; In methanol;

DOI:10.1021/jm00009a015

upstream raw materials:

(+/-)-cis-3-methyl-N-phenyl-4-piperidinamine

1-benzyl-3-methyl-N-phenyl-4-piperidinamine

1-Benzyl-3-methyl-4-piperidon

(+/-)-cis-1-benzyl-3-methyl-N-phenylpiperidinamine

Downstream raw materials:

(3S,4R,2'R)-cis-3-methyl-1-(2-hydroxy-2-phenylethyl)-N-phenyl-4-piperidinamine

(3S,4R)-(-)-cis-N-<3-methyl-1-<2-(4-nitrophenyl)ethyl>-4-piperidyl>-N-phenylpropanamide

(3S,4R,2'S)-cis-N-<1-<2-(propionyloxy)-2-phenylethyl>-3-methyl-4-piperidyl>-N-phenylpropanamide

(3S,4R,2'R)-cis-N-<1-<2-(propionyloxy)-2-phenylethyl>-3-methyl-4-piperidyl>-N-phenylpropanamide

Refernces

• 1、 Wang,Zhu,Jin,Chen,Chen,Ji,Chi. "Stereoisomers of N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl]-N- phenylpropanamide: Synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics". . p. 3652 - 3659. Retrieved 2007/10/03.