(2R)-6-methoxy-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromene

Base Information

• Chemical Name: (2R)-6-methoxy-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromene
• CAS No.: 32466-45-8
• Molecular Formula: C30H52 O2
• Molecular Weight: 444.742
• Mol file: 32466-45-8.mol

Synonyms:2H-1-Benzopyran,3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,[2R-[2R*(4R*,8R*)]]-; Chroman,6-methoxy-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, (+)- (8CI);(R,R,R)-O-Methyl-a-tocopherol;(R,R,R)-a-Tocopherol methyl ether; a-Tocopherol methyl ether

Chemical Property of (2R)-6-methoxy-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromene

Chemical Property:

• Vapor Pressure: 2.48E-10mmHg at 25°C
• Boiling Point: 518.3°C at 760 mmHg
• Flash Point: 144°C
• Density: 0.91g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-6-methoxy-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromene

There total 45 articles about (2R)-6-methoxy-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C30H50O2 → (2R,4'R,8'R)-α-tocopheryl methyl ether (32466-45-8)

Guidance literature:

With hydrogen; In ethanol; at 20 ℃; for 20h; under 7500.75 Torr; enantioselective reaction; Inert atmosphere; Autoclave;

DOI:10.1002/chem.201900564

Reference yield: 97.0%

(R)-6-methoxy-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)chroman-4-one → (2R,4'R,8'R)-α-tocopheryl methyl ether (32466-45-8)

Guidance literature:

With palladium on activated carbon; hydrogen; acetic acid; at 70 ℃; for 96h; under 750.075 Torr;

Reference yield: 95.0%

(R,R,R)-α-3,4-dehydrotocopherol methyl ether → (2R,4'R,8'R)-α-tocopheryl methyl ether (32466-45-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 0.5h; under 750.075 Torr;

DOI:10.1002/chem.200902754

upstream raw materials:

Tocopherol

methyl iodide

C₃₁H₅₂O₄

C₃₁H₅₂O₃

Downstream raw materials:

Tocopherol

2-[(3R,7R,11R)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione

Refernces

• 1、 Mori, Tadashi,Izumi, Hiroshi,Inoue, Yoshihisa. "Chiroptical properties of organic radical cations. The electronic and vibrational circular dichroism spectra of α-tocopherol derivatives and sterically hindered chiral hydroquinone ethers". . p. 9540 - 9549. Retrieved 2004.
• 2、 Tsubogo, Tetsu,Aoyama, Saki,Takeda, Rika,Uchiro, Hiromi. "Synthesis of 2,2-dialkyl chromanes by intramolecular Ullmann C–O coupling reactions toward the total synthesis of D-α-tocopherol". . p. 843 - 846. Retrieved 2018/09/10.
• 3、 -. "SYNTHESIS OF CHROMANE COMPOUNDS AND THEIR DERIVATIVES BY A COPPER-CATALYZED CONJUGATE ADDITION REACTION". . . Retrieved 2015/05/06.