ETHYL 3-BUTYNOATE

Base Information

• Chemical Name: ETHYL 3-BUTYNOATE
• CAS No.: 53841-07-9
• Molecular Formula: C6H8O2
• Molecular Weight: 112.128
• Hs Code.: 2916190090
• Mol file: 53841-07-9.mol

Synonyms:ETHYL 3-BUTYNOATE

Chemical Property of ETHYL 3-BUTYNOATE

Chemical Property:

• Boiling Point: 104-105 °C(Press: 190 Torr)
• PSA: 26.30000
• Density: 0.976±0.06 g/cm3(Predicted)
• LogP: 0.57280

Purity/Quality:

99% ^*data from raw suppliers

ethylbut-3-ynoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-BUTYNOATE

There total 5 articles about ETHYL 3-BUTYNOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl acetoacetate (141-97-9) → ethyl cyanoacetate (53841-07-9)

Guidance literature:

ethyl acetoacetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.75h; Inert atmosphere;

With trifluoromethylsulfonic anhydride; In tetrahydrofuran; at -78 ℃; for 1.25h; Further stages; Ineret atmosphere;

DOI:10.1021/jo801563x

Reference yield: 49.0%

diazoacetic acid ethyl ester (623-73-4) + acetylene (74-86-2,25067-58-7) → ethyl cyanoacetate (53841-07-9)

Guidance literature:

With copper(II) oxide; at 170 ℃;

DOI:10.1007/BF01168281

Reference yield:

C6H10O2 → ethyl cyanoacetate (53841-07-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; Green chemistry;

DOI:10.1039/d1gc02856a

upstream raw materials:

ethanol

3-butynoic acid

diazoacetic acid ethyl ester

acetylene

Downstream raw materials:

ethyl 1-(benzyl)-1H-1,2,3-triazole-4-carboxylate

2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid ethyl ester

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

ethyl 2-amino-4H,5H,6H-cyclopentenothiophene-3-carboxylate

Refernces

• 1、 Maity, Pradip,Lepore, Salvatore D.. "Selective one-pot synthesis of allenyl and alkynyl esters from β-ketoesters". supporting information; experimental part. p. 158 - 162. Retrieved 2009/04/07.