(R)-Homo-beta-alanine hydrochloride

Base Information

• Chemical Name: (R)-Homo-beta-alanine hydrochloride
• CAS No.: 58610-42-7
• Molecular Formula: C4H10ClNO2
• Molecular Weight: 139.5807
• Mol file: 58610-42-7.mol

Synonyms:H-D-β-HoAla-OH.HCl;(R)-3-Amino-butyric acid hydrochloride;D-beta-homoalanine-HCl;

Chemical Property of (R)-Homo-beta-alanine hydrochloride

Chemical Property:

• Vapor Pressure: 0.00526mmHg at 25°C
• Refractive Index: ">
• Boiling Point: 254.7°Cat760mmHg
• Flash Point: 107.8°C
• PSA: 63.32000
• LogP: 1.31060
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.3% ^*data from raw suppliers

(R)-3-Aminobutanoicacidhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-Homo-beta-alanine hydrochloride

There total 9 articles about (R)-Homo-beta-alanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-3-(benzylamino)butanoic acid hydrochloride (1253735-39-5) → (3S)-3-aminobutanoic acid hydrochloride (58610-41-6,58610-42-7)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In water; at 65 - 70 ℃; for 22h; under 3361.55 Torr;

DOI:10.1039/c002721a

Reference yield: 96.0%

diethyl 2-(1-tert-butoxycarbonylamino-ethyl)malonate → β-aminobutyric acid hydrochloride (5959-33-1,58610-42-7)

Guidance literature:

With hydrogenchloride; In water; for 1h; Heating;

DOI:10.1016/j.tet.2005.04.077

Reference yield: 94.0%

(RS)-2-methyl-2,3-dihydro-1H-pyridin-4-one (34697-37-5) → β-aminobutyric acid hydrochloride (5959-33-1,58610-42-7)

Guidance literature:

(RS)-2-methyl-2,3-dihydro-1H-pyridin-4-one; With sodium periodate; In water; at 20 ℃; for 2h;

With sodium hydroxide; In water; at 20 ℃; for 24h;

DOI:10.1021/ol0485518

upstream raw materials:

DL-3-acetylamino butanoic acid ethyl ester

(+-)-3-amino-butyronitrile

(RS)-2-methyl-2,3-dihydro-1H-pyridin-4-one

(S)-methyl 3-aminobutanoate

Refernces

• 1、 Weiss, Markus,Brinkmann, Tobias,Groeger, Harald. "Towards a greener synthesis of (S)-3-aminobutanoic acid: Process development and environmental assessment". supporting information; experimental part. p. 1580 - 1588. Retrieved 2010/12/19.
• 2、 Sleebs, Brad E.,Hughes, Andrew B.. "Diastereoselective synthesis of α-methyl and α-hydroxy-β- amino acids via 4-substituted-1,3-oxazinan-6-ones". . p. 3340 - 3352. Retrieved 2008/02/08.