5-METHYL-2-NITROBENZALDEHYDE

Base Information

• Chemical Name: 5-METHYL-2-NITROBENZALDEHYDE
• CAS No.: 5858-28-6
• Molecular Formula: C8H7NO3
• Molecular Weight: 165.148
• Hs Code.: 2913000090
• Mol file: 5858-28-6.mol

Synonyms:5-METHYL-2-NITROBENZALDEHYDE

Chemical Property of 5-METHYL-2-NITROBENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 64 °C
• Refractive Index: 1.603
• Boiling Point: 314.018°C at 760 mmHg
• Flash Point: 158.318°C
• PSA: 62.89000
• Density: 1.278g/cm³
• LogP: 2.23890
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

5-methyl-2-nitrobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-2-NITROBENZALDEHYDE

There total 6 articles about 5-METHYL-2-NITROBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-methyl-2-nitrobenzyl alcohol (66424-92-8) → 5-methyl-2-nitrobenzaldehyde (5858-28-6)

Guidance literature:

5-methyl-2-nitrobenzyl alcohol; With oxalyl dichloride; In dichloromethane; dimethyl sulfoxide; at -60 ℃; for 1.08333h;

With triethylamine; In dichloromethane; dimethyl sulfoxide; at -60 - 20 ℃;

Reference yield: 97.0%

2-(5-methyl-2-nitro-benzyloxy)-tetrahydro-pyran (218623-11-1) → 5-methyl-2-nitrobenzaldehyde (5858-28-6)

Guidance literature:

With chromium(VI) oxide; HZSM-5 zeolite; for 0.0333333h; microwave irradiation;

DOI:10.1080/10426500214895

Reference yield: 93.0%

trimethyl-(5-methyl-2-nitro-benzyloxy)-silane → 5-methyl-2-nitrobenzaldehyde (5858-28-6)

Guidance literature:

With chromium(VI) oxide; Hexamethyldisiloxane; silica gel; In dichloromethane; for 0.25h; Ambient temperature;

DOI:10.1080/00397919908086064

upstream raw materials:

5-methyl-2-nitrobenzyl alcohol

2-(5-methyl-2-nitro-benzyloxy)-tetrahydro-pyran

(5-methyl-2-nitro-phenyl)-pyruvic acid

oxalyl dichloride

Downstream raw materials:

1-Methyl-5-[1-(5-methyl-2-nitro-phenyl)-meth-(Z)-ylidene]-imidazolidine-2,4-dione

C₉H₈N₂O₄

Refernces

• 1、 Le, Thanh Nguyen,Yang, Su Hui,Khadka, Daulat Bikram,Cho, Suk Hee,Zhao, Chao,Cho, Won-Jea. "Synthetic approaches to natural antioxidant benzastatin E, F and G analogues". experimental part. p. 4309 - 4315. Retrieved 2012/03/26.
• 2、 -. "Benzimidazole derivatives". Page 22. . Retrieved 2010/02/05.