1-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)ethanone

Base Information

• Chemical Name: 1-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)ethanone
• CAS No.: 545394-33-0
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.245
• Hs Code.: 2933499090
• Mol file: 545394-33-0.mol

Synonyms:1,2,3,4-Tetrahydro-1-acetyl-7-quinolinamine;1-Acetyl-7-amino-1,2,3,4-tetrahydroquinoline;

Chemical Property of 1-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)ethanone

Chemical Property:

• Melting Point: 76-78 °C
• Boiling Point: 462.4 °C at 760 mmHg
• PKA: 4.79±0.20(Predicted)
• Flash Point: 233.5 °C
• PSA: 46.33000
• Density: 1.182 g/cm³
• LogP: 2.21410
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-(7-amino-3,4-dihydroquinolin-1(2H)-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)ethanone

There total 4 articles about 1-(7-Amino-3,4-dihydroquinolin-1(2H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-acetyl-7-nitro-1,2,3,4-tetrahydroquinoline (40484-66-0) → (N-acetyl-1,2,3,4-tetrahydroquinolin-7-yl)amine (545394-33-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201000343

Reference yield:

7-nitro-1,2,3,4-tetrahydro-quinoline (30450-62-5) → (N-acetyl-1,2,3,4-tetrahydroquinolin-7-yl)amine (545394-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: platinum; ethyl acetate; methanol / Hydrogenation

With pyridine; methanol; ethyl acetate; platinum;

DOI:10.1139/v52-084

Reference yield:

1-acetyl-1,2,3,4-tetrahydroquinoline (4169-19-1) → (N-acetyl-1,2,3,4-tetrahydroquinolin-7-yl)amine (545394-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium nitrate; concentrated sulfuric acid / Erhitzen des Reaktionsprodukts mit wss. Salzsaeure

2: pyridine

3: platinum; ethyl acetate; methanol / Hydrogenation

With pyridine; methanol; sulfuric acid; ethyl acetate; potassium nitrate; platinum;

DOI:10.1139/v52-084

upstream raw materials:

N-acetyl-7-nitro-1,2,3,4-tetrahydroquinoline

1-acetyl-1,2,3,4-tetrahydroquinoline

7-nitro-1,2,3,4-tetrahydro-quinoline

Refernces

• 1、 Kolmakov, Kirill,Belov, Vladimir N.,Wurm, Christian A.,Harke, Benjamin,Leutenegger, Marcel,Eggeling, Christian,Hell, Stefan W.. "A versatile route to red-emitting carbopyronine dyes for optical microscopy and nanoscopy". supporting information; experimental part. p. 3593 - 3610. Retrieved 2010/11/18.
• 2、 -. "Vanilloid receptor ligands and their use in treatments". . . Retrieved 2008/06/13.