Difluoromethyldimethylamine

Base Information

• Chemical Name: Difluoromethyldimethylamine
• CAS No.: 683-81-8
• Molecular Formula: C3H7F2N
• Molecular Weight: 95.09
• Hs Code.: 2921199090
• European Community (EC) Number: 673-915-1
• DSSTox Substance ID: DTXSID20374270
• Wikidata: Q82162800
• Mol file: 683-81-8.mol

Synonyms:Difluoromethyldimethylamine;683-81-8;1,1-difluoro-N,N-dimethylmethanamine;Difluoromethyl(dimethyl)amine;(difluoromethyl)dimethylamine;difluoromethyldimethyl-amine;Difluoromethyl dimethylamine;DTXSID20374270;PULPCFLUVFWKAF-UHFFFAOYSA-N;AKOS005259287;1,1-bis(fluoranyl)-N,N-dimethyl-methanamine;FT-0690781;A836125

Chemical Property of Difluoromethyldimethylamine

Chemical Property:

• Vapor Pressure: 1110mmHg at 25°C
• Refractive Index: 1.334
• Boiling Point: 14.7°C at 760 mmHg
• PKA: 1.27±0.70(Predicted)
• PSA: 3.24000
• Density: 0.984g/cm³
• LogP: 0.77060
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 95.05465555
• Heavy Atom Count: 6
• Complexity: 35.8

Purity/Quality:

98%Min ^*data from raw suppliers

DIFLUOROMETHYLDIMETHYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 34
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(F)F

Technology Process of Difluoromethyldimethylamine

There total 4 articles about Difluoromethyldimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → α,α-difluorotrimethylamine (683-81-8)

Guidance literature:

With Carbonyl fluoride; at -196 - 20 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ic400756z

Reference yield: 75.0%

1,1-dichloromethyl-N,N-dimethylamine (25818-74-0) → α,α-difluorotrimethylamine (683-81-8)

Guidance literature:

With hydrogen fluoride; at 0 ℃; for 3h; Inert atmosphere;

Reference yield: 75.0%

→ α,α-difluorotrimethylamine (683-81-8)

Guidance literature:

upstream raw materials:

N,N-dimethyl-formamide

Carbonyl fluoride

1,1-dichloromethyl-N,N-dimethylamine

Downstream raw materials:

dimethylaminosulfur trifluoride

Refernces

• 1、 -. "Fluorinating agent and synthesis method thereof". Paragraph 0054-0056. . Retrieved 2020/09/16.
• 2、 -. "Fluorinating reactants and process for their preparation". Page 11. . Retrieved 2010/02/07.