2-Chloro-4-methylquinazoline

Base Information

• Chemical Name: 2-Chloro-4-methylquinazoline
• CAS No.: 6141-14-6
• Molecular Formula: C9H7ClN2
• Molecular Weight: 178.621
• Hs Code.: 2933990090
• Mol file: 6141-14-6.mol

Synonyms:2-Chloro-4-methylquinazoline

Chemical Property of 2-Chloro-4-methylquinazoline

Chemical Property:

• Vapor Pressure: 0.0174mmHg at 25°C
• Refractive Index: 1.643
• Boiling Point: 262.8 °C at 760 mmHg
• PKA: 0.94±0.30(Predicted)
• Flash Point: 138.2 °C
• PSA: 25.78000
• Density: 1.292g/cm³
• LogP: 2.59160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-methylquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-methylquinazoline

There total 7 articles about 2-Chloro-4-methylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2,4-dichloroquinazoline (607-68-1) + trimethylaluminum (75-24-1) → 2-chloro-4-methylquinazoline (6141-14-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 24h; Heating;

DOI:10.1016/0040-4039(95)02381-X DOI:10.3891/acta.chem.scand.51-0302

Reference yield: 67.0%

4-methyl-1,2-dihydro-2-oxoquinazoline (34790-24-4) → 2-chloro-4-methylquinazoline (6141-14-6)

Guidance literature:

With trichlorophosphate; In hydrogenchloride;

Reference yield:

2,4-dichloroquinazoline (607-68-1) + methylmagnesium chloride (676-58-4) → 2-chloro-4-methylquinazoline (6141-14-6)

Guidance literature:

With zinc dibromide; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2010.10.126

upstream raw materials:

2,4-dichloroquinazoline

trimethylaluminum

4-methyl-1,2-dihydro-2-oxoquinazoline

methylmagnesium chloride

Downstream raw materials:

3-phenyl-5-(piperidin-1-yl)imidazo[1,5-c]quinazoline

4-(3-phenylimidazo[1,5-c]quinazolin-5-yl)morpholine

Refernces

• 1、 Zhao, Dan,Wang, Teng,Shen, Qi,Li, Jian-Xin. "N-Bu4NI-catalyzed selective dual amination of sp3 C-H bonds: Oxidative domino synthesis of imidazo[1,5-c]quinazolines on a gram-scale". supporting information. p. 4302 - 4304. Retrieved 2014/04/17.
• 2、 -. "QUINAZOLINE COMPOUNDS AND THEIR USE IN MCH-RELATED DISEASE". Page/Page column 7. . Retrieved 2008/06/13.