(3R)-1-(2-Aminoethyl)-3-pyrrolidinol

Base Information

• Chemical Name: (3R)-1-(2-Aminoethyl)-3-pyrrolidinol
• CAS No.: 672325-36-9
• Molecular Formula: C6H14N2O
• Molecular Weight: 130.19
• Mol file: 672325-36-9.mol

Synonyms:EN001523;(3R)-1-(2-Aminoethyl)pyrrolidin-3-ol;3-Pyrrolidinol, 1-(2-aminoethyl)-, (3R)-;

Chemical Property of (3R)-1-(2-Aminoethyl)-3-pyrrolidinol

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.53
• Boiling Point: 245.286 °C at 760 mmHg
• Flash Point: 102.146 °C
• PSA: 49.49000
• Density: 1.103 g/cm³
• LogP: -0.35010
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-1-(2-Aminoethyl)pyrrolidin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3R)-1-(2-Aminoethyl)-3-pyrrolidinol

There total 1 articles about (3R)-1-(2-Aminoethyl)-3-pyrrolidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

NCCH2N(CH2)3CHOH → 1-(2-aminoethyl)-3-(R)-hydroxy-pyrrolidine (672325-36-9,540787-75-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 75 ℃; for 2.5h;

DOI:10.1016/j.bmc.2007.05.068

Reference yield: 76.0%

1-(2-aminoethyl)-3-(R)-hydroxy-pyrrolidine (672325-36-9,540787-75-5) + 3-(1-methyl-4-oxo-cyclohexyl)-benzonitrile (849697-66-1) → 3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile (869708-40-7)

Guidance literature:

With sodium tris(acetoxy)borohydride; In dichloromethane; Heating;

DOI:10.1021/jm049035q

Reference yield: 61.0%

1-(2-aminoethyl)-3-(R)-hydroxy-pyrrolidine (672325-36-9,540787-75-5) + 6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-one (540787-79-9) → C20H27N3O (869708-42-9)

Guidance literature:

1-(2-aminoethyl)-3-(R)-hydroxy-pyrrolidine; 6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-one; With titanium(IV) isopropylate; In dichloromethane; at 20 ℃; for 3h;

With sodium tetrahydroborate; In dichloromethane; at 0 ℃; for 4h; Further stages.;

DOI:10.1016/j.bmc.2007.05.068

Downstream raw materials:

3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-cyclohexyl}-benzonitrile

3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-1-methyl-cyclohexyl}-benzonitrile

3-{(1S,4R,5S)-4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-bicyclo[3.1.0]hex-1-yl}-benzonitrile

3-{4-[2-((R)-3-Hydroxy-pyrrolidin-1-yl)-ethylamino]-bicyclo[4.1.0]hept-1-yl}-benzonitrile

Refernces