5-Nitro indazole carboxaldehyde

Base Information

• Chemical Name: 5-Nitro indazole carboxaldehyde
• CAS No.: 677702-36-2
• Molecular Formula: C8H5N3O3
• Molecular Weight: 191.14
• Hs Code.: 2933990090
• Mol file: 677702-36-2.mol

Synonyms:5-Nitro-1H-indazole-3-carbaldehyde;

Chemical Property of 5-Nitro indazole carboxaldehyde

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 300℃
• Refractive Index: 1.783
• Boiling Point: 463.463 °C at 760 mmHg
• PKA: 9.75±0.40(Predicted)
• Flash Point: 234.094 °C
• PSA: 91.57000
• Density: 1.612 g/cm³
• LogP: 1.80680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Nitro-1H-indazole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Nitro indazole carboxaldehyde

There total 3 articles about 5-Nitro indazole carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-nitroindole (6146-52-7) → 5-nitro-1H-indazole-3-carboxaldehyde (677702-36-2)

Guidance literature:

With hydrogenchloride; water; sodium nitrite; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 6h; Temperature; Inert atmosphere;

DOI:10.1039/c8ra01546e

Reference yield: 92.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 5-nitroindazole (5401-94-5) → 5-nitro-1H-indazole-3-carboxaldehyde (677702-36-2)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; at 0 - 5 ℃; for 0.5h;

5-nitroindazole; at 0 - 20 ℃; for 3h;

With water; sodium hydroxide;

DOI:10.1007/s00706-016-1750-6

Reference yield:

→ 5-nitro-1H-indazole-3-carboxaldehyde (677702-36-2)

Guidance literature:

upstream raw materials:

N,N-dimethyl-formamide

5-nitroindazole

5-nitroindole

Downstream raw materials:

methyl 5-nitro-1H-indazole-3-carboxylate

5-Nitro-1-(2,4,6-trimethylbenzenesulphonyl)-1H-indazole-3-carbaldehyde

Refernces

• 1、 Rudavath, Durgesh,Sreenivasulu, Reddymasu,Pinapati, Srinivasa Rao,Raju, Rudraraju Ramesh. "Synthesis and anticancer evaluation of indazole-aryl hydrazide-hydrazone derivatives". . p. 433 - 438. Retrieved 2020/06/29.
• 2、 -. "Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors". Page/Page column 17. . Retrieved 2008/06/13.