(16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol

Base Information

• Chemical Name: (16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol
• CAS No.: 793-89-5
• Molecular Formula: C18H24O3
• Molecular Weight: 288.387
• Mol file: 793-89-5.mol

Synonyms:(16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol

Chemical Property of (16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol

Chemical Property:

• PSA: 60.69000
• LogP: 2.58000

Purity/Quality:

99%min ^*data from raw suppliers

1,3,5(10)-ESTRATRIEN-3,16-BETA-17-ALPHA-TRIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: trans-Estriol is a metabolite of Estradiol (E888000). It has distinct preferential binding affinity for human ERβ over ERα.

Technology Process of (16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol

There total 14 articles about (16b,17a)-Estra-1,3,5(10)-triene-3,16,17-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ estriol (50-27-1,547-81-9,651-50-3,793-89-5,1228-72-4,21610-95-7,300853-07-0)

Guidance literature:

Die radioaktive Verbindung findet sich als 3-Glucuronid im Harn v. Menschen nach Verabfolgung v. <7α-³H>-Androstenolon-<¹⁴C>glucuronid;

Reference yield:

3,16α-diacetoxy-1,3,5(10)-estratrien-17-one (1247-71-8) → Estriol (50-27-1,300853-07-0) + 17-epiestriol (50-27-1,547-81-9,651-50-3,793-89-5,21610-95-7,1228-72-4,300853-07-0)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/jo01361a025

Reference yield:

3-Hydroxyestra-1,3,5(10)-triene 16β,17β-Oxide (472-57-1) → Estriol (50-27-1,300853-07-0) + 16,17-Epiestriol (793-89-5,300853-07-0)

Guidance literature:

With acetic acid; Erwaermen des Reaktionsprodukts mit aethanol. KOH;

DOI:10.1021/jo01102a028

upstream raw materials:

3,16α-diacetoxy-1,3,5(10)-estratrien-17-one

3-Hydroxyestra-1,3,5(10)-triene 16β,17β-Oxide

estra-1,3,5⁽¹⁰⁾,16-tetraene-3,17-diol diacetate

16α-bromo-3-hydroxy-1,3,5(10)-estratrien-17-one 3-acetate

Refernces

• 1、 Hosoda,Yamashita,Nambara. "Syntheses of 15α hydroxyestrone and 15α hydroxyestradiol". . p. 3141 - 3145. Retrieved 2007/10/12.
• 2、 OZON. "ANALYSIS, IN VIVO, OF ESTROGEN METABOLISM DURING SEXUAL DIFFERENTIATION". . p. 2332 - 2335. Retrieved 2007/10/06.