1-Boc-4-fluoro-4-piperidinecarboxylic acid

Base Information

• Chemical Name: 1-Boc-4-fluoro-4-piperidinecarboxylic acid
• CAS No.: 614731-04-3
• Molecular Formula: C11H18FNO4
• Molecular Weight: 247.26
• Hs Code.: 2933399090
• Mol file: 614731-04-3.mol

Synonyms:1-BOC-4-FLUORO-4-PIPERIDINECARBOXYLIC ACID;1-(tert-butoxycarbonyl)-4-fluoropiperidine-4-carboxylic acid;1-Boc-4-fluoropiperidine-4-carboxylic acid;1-Boc-4-fluoropiperidine-...;1,4-Piperidinedicarboxylic acid, 4-fluoro-, 1-(1,1-diMethylethyl) ester;1-(tert-Butoxycarbonyl)-4-fluoropiperidine-4-carboxylic acid, 1-(tert-Butoxycarbonyl)-4-carboxy-4-fluoropiperidine;4-Fluoropiperidine-4-carboxylic acid, N-BOC protected 95%

Chemical Property of 1-Boc-4-fluoro-4-piperidinecarboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.49
• Boiling Point: 346.275 °C at 760 mmHg
• PKA: 2.44±0.20(Predicted)
• Flash Point: 163.221 °C
• PSA: 66.84000
• Density: 1.223 g/cm³
• LogP: 1.74810
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Fluoropiperidine-4-carboxylic acid, N-Boc protected 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-4-fluoro-4-piperidinecarboxylic acid

There total 2 articles about 1-Boc-4-fluoro-4-piperidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-fluoropiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (416852-82-9) → 1-[(tert-butoxy)carbonyl]-4-fluoropiperidine-4-carboxylic acid (614731-04-3)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; at 80 ℃;

Reference yield:

1-tert-butyl 4-methyl 4-fluoropiperidine-1,4-dicarboxylate (1048994-21-3) → 1-[(tert-butoxy)carbonyl]-4-fluoropiperidine-4-carboxylic acid (614731-04-3)

Guidance literature:

4-fluoro-1-(1,1-dimethylethyl)-1,4-piperidinedicarboxylic acid 4-methyl ester; With sodium hydroxide; ethanol; water; at 20 - 60 ℃;

With hydrogenchloride; water; In ethanol;

Reference yield: 100.0%

1-[(tert-butoxy)carbonyl]-4-fluoropiperidine-4-carboxylic acid (614731-04-3) → 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylic acid tert-butyl ester (614730-97-1)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃; for 5h;

upstream raw materials:

1-tert-butyl 4-methyl 4-fluoropiperidine-1,4-dicarboxylate

4-fluoropiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Downstream raw materials:

4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylic acid tert-butyl ester

4-carbamoyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

4-cyano-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester

4-fluoropiperidine-4-carbonitrile

Refernces

• 1、 -. "BENZOFURAN COMPOUNDS". Page/Page column 32-33. . Retrieved 2008/12/08.