4-(3-FLUOROBENZOYL)PIPERIDINE

Base Information

• Chemical Name: 4-(3-FLUOROBENZOYL)PIPERIDINE
• CAS No.: 639468-63-6
• Molecular Formula: C12H14 F N O
• Molecular Weight: 207.24
• Hs Code.: 2933399990
• Mol file: 639468-63-6.mol

Synonyms:4-(3-FLUOROBENZOYL)PIPERIDINE

Chemical Property of 4-(3-FLUOROBENZOYL)PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.00038mmHg at 25°C
• Refractive Index: 1.522
• Boiling Point: 317.6°C at 760 mmHg
• PKA: 9.67±0.10(Predicted)
• Flash Point: 145.9°C
• Density: 1.128g/cm³
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(3-Fluorobenzoyl)piperidine ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-FLUOROBENZOYL)PIPERIDINE

There total 4 articles about 4-(3-FLUOROBENZOYL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3-fluorobenzoyl)piperidine-1-carboxylic acid tert-butyl ester (269741-29-9) → (3-fluorophenyl)(piperidin-4-yl)methanone (639468-63-6)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Heating;

DOI:10.1021/jm0309349

Reference yield:

4-cyanopiperidine (4395-98-6) → (3-fluorophenyl)(piperidin-4-yl)methanone (639468-63-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 79 percent / NaHCO₃ / 20 h / 20 °C

2.1: Mg; I₂ / diethyl ether / 1.5 h / Heating

2.2: diethyl ether / 3 h / Heating

3.1: aq.HCl / methanol / 2 h / Heating

With hydrogenchloride; iodine; sodium hydrogencarbonate; magnesium; In methanol; diethyl ether;

DOI:10.1021/jm0309349

Reference yield:

4-carboxamidopiperidine (39546-32-2) → (3-fluorophenyl)(piperidin-4-yl)methanone (639468-63-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 86 percent / SOCl₂ / 3 h / Heating

2.1: 79 percent / NaHCO₃ / 20 h / 20 °C

3.1: Mg; I₂ / diethyl ether / 1.5 h / Heating

3.2: diethyl ether / 3 h / Heating

4.1: aq.HCl / methanol / 2 h / Heating

With hydrogenchloride; thionyl chloride; iodine; sodium hydrogencarbonate; magnesium; In methanol; diethyl ether;

DOI:10.1021/jm0309349

upstream raw materials:

4-(3-fluorobenzoyl)piperidine-1-carboxylic acid tert-butyl ester

4-cyanopiperidine

4-carboxamidopiperidine

1-tert-butoxycarbonyl-4-cyanopiperidine

Downstream raw materials:

(+)-(3-fluorophenyl)(piperidin-4-yl)methanol

(-)-(3-fluorophenyl)(piperidin-4-yl)methanol

(3-fluorophenyl)(piperidin-4-yl)methanol

Refernces