N-(pyridin-2-yl)hydrazinecarboxamide

Base Information

• Chemical Name: N-(pyridin-2-yl)hydrazinecarboxamide
• CAS No.: 64341-20-4
• Molecular Formula: C₆H₈N₄O
• Molecular Weight: 152.156
• European Community (EC) Number: 862-546-3
• Nikkaji Number: J3.294.163J
• Mol file: 64341-20-4.mol

Synonyms:N-(pyridin-2-yl)hydrazinecarboxamide;1-amino-3-pyridin-2-ylurea;64341-20-4;SCHEMBL8665367;AKOS017394407;Hydrazinecarboxamide, N-2-pyridinyl-;3-AMINO-1-(PYRIDIN-2-YL)UREA;EN300-74907

Chemical Property of N-(pyridin-2-yl)hydrazinecarboxamide

Chemical Property:

• PSA: 80.04000
• LogP: 1.24100
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 152.06981089
• Heavy Atom Count: 11
• Complexity: 139

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)NC(=O)NN

Technology Process of N-(pyridin-2-yl)hydrazinecarboxamide

There total 4 articles about N-(pyridin-2-yl)hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

phenyl N-(pyridin-2-yl)carbamate (20951-00-2) → 4-pyridin-2-ylsemicarbazide (64341-20-4)

Guidance literature:

With hydrazine hydrate; In water; acetonitrile; at 20 ℃; for 3h; Sonication;

DOI:10.1016/j.tetlet.2014.01.052

Reference yield: 80.0%

ethyl 2-pyridinylcarbamate (5255-67-4) → 4-pyridin-2-ylsemicarbazide (64341-20-4)

Guidance literature:

With hydrazine hydrate; at 80 ℃; for 12h;

DOI:10.1016/j.tetlet.2014.01.052

Reference yield:

2-aminopyridine (504-29-0) → 4-pyridin-2-ylsemicarbazide (64341-20-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / 0.08 h / 0 - 20 °C

2: hydrazine hydrate / water; acetonitrile / 3 h / 20 °C / Sonication

With hydrazine hydrate; sodium hydrogencarbonate; In tetrahydrofuran; water; acetonitrile;

DOI:10.1016/j.tetlet.2014.01.052

upstream raw materials:

2-aminopyridine

acetone semicarbazone

phenyl N-(pyridin-2-yl)carbamate

ethyl 2-pyridinylcarbamate

Refernces

• 1、 Hron, Rebecca,Jursic, Branko S.. "Preparation of substituted semicarbazides from corresponding amines and hydrazines via phenyl carbamates". . p. 1540 - 1543. Retrieved 2014/03/21.