Technology Process of 2-(BENZYLOXY)-5-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
There total 7 articles about 2-(BENZYLOXY)-5-(TRIFLUOROMETHYL)PHENYLBORONIC ACID which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-benzyloxy-5-(trifluoromethyl)-iodobenzene;
With
isopropylmagnesium chloride;
In
tetrahydrofuran; diethyl ether;
at -40 ℃;
for 0.666667h;
With
Trimethyl borate;
In
tetrahydrofuran; diethyl ether;
at -75 - 0 ℃;
for 1.16667h;
With
hydrogenchloride; water;
In
tetrahydrofuran; diethyl ether;
for 1h;
- Guidance literature:
-
1-(benzyloxy)-2-bromo-4-(trifluoromethyl)benzene;
With
n-butyllithium;
In
tetrahydrofuran; hexanes;
at -100 - -78 ℃;
for 1.33333h;
Cooling with diethyl ether/liquid nitrogen;
Cooling with acetone/Drikold;
With
Triisopropyl borate;
In
tetrahydrofuran; hexanes;
at -78 - 20 ℃;
for 1.5h;
Cooling with acetone/Drikold;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / acetone / 2 h / Heating / reflux
2.1: n-butyllithium / tetrahydrofuran; hexanes / 1.33 h / -100 - -78 °C / Cooling with diethyl ether/liquid nitrogen; Cooling with acetone/Drikold
2.2: 1.5 h / -78 - 20 °C / Cooling with acetone/Drikold
With
n-butyllithium; potassium carbonate;
In
tetrahydrofuran; hexanes; acetone;