2,2,2-TRIFLUOROETHYL 2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOATE

Base Information

• Chemical Name: 2,2,2-TRIFLUOROETHYL 2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOATE
• CAS No.: 50778-57-9
• Molecular Formula: C13H9 F9 O4
• Molecular Weight: 400.198
• Mol file: 50778-57-9.mol

Synonyms:2,2,2-Trifluoroethyl2,5-bis(2,2,2-trifluoroethoxy)benzoate

Chemical Property of 2,2,2-TRIFLUOROETHYL 2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOATE

Chemical Property:

• Vapor Pressure: 0.000674mmHg at 25°C
• Boiling Point: 308.6oC at 760 mmHg
• Flash Point: 135.9oC
• PSA: 44.76000
• Density: 1.46g/cm3
• LogP: 4.28790
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol

Purity/Quality:

99%, ^*data from raw suppliers

2,2,2-Trifluoroethyl2,5-Bis(2,2,2-trifluoroethoxy)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the production of antiarrhythmic N-(Piperidylalkyl)trifluoroethoxybenzamides. Possible Flecainide impurity.

Technology Process of 2,2,2-TRIFLUOROETHYL 2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOATE

There total 2 articles about 2,2,2-TRIFLUOROETHYL 2,5-BIS(2,2,2-TRIFLUOROETHOXY)BENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trifluoroethyl trifluoromethanesulphonate (6226-25-1) + 2,5-dihydroxybenzoic acid. (490-79-9) → 2,2,2-trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate (50778-57-9)

Guidance literature:

With potassium hydrogencarbonate; In water; acetone;

Reference yield:

→ 2,2,2-trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate (50778-57-9)

Guidance literature:

2.2.2-Trifluoroethyl-trifluoromethansulfonat, K2CO3, sd. Acn., 2.5-Dihydroxybenzoesaeure in Acn.;

DOI:10.1021/jm00245a017

Reference yield:

C-piperidin-2-yl-methylamine (22990-77-8,111478-74-1,111478-77-4) + 2,2,2-trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate (50778-57-9) → flecainide hydrochloride (57415-44-8)

Guidance literature:

C-piperidin-2-yl-methylamine; 2,2,2-trifluoroethyl 2,5-bis(2,2,2-trifluoroethoxy)benzoate; In benzene; at 45 ℃; for 40h;

With hydrogenchloride; In isopropyl alcohol; at 2 ℃;

upstream raw materials:

2,2,2-trifluoroethyl trifluoromethanesulphonate

2,5-dihydroxybenzoic acid.

Downstream raw materials:

N-(1-ethyl-piperidin-2-ylmethyl)-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide

flecainide hydrochloride

N-piperidin-4-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide

N-(1-piperidin-2-yl-ethyl)-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide

Refernces