2-ACETAMIDO-5-BROMOTHIAZOLE

Base Information

• Chemical Name: 2-ACETAMIDO-5-BROMOTHIAZOLE
• CAS No.: 7336-54-1
• Molecular Formula: C5H5BrN2OS
• Molecular Weight: 221.077
• Hs Code.: 2934100090
• Mol file: 7336-54-1.mol

Synonyms:2-Acetamido-5-bromothiazole;

Chemical Property of 2-ACETAMIDO-5-BROMOTHIAZOLE

Chemical Property:

• Refractive Index: 1.657
• PSA: 70.23000
• Density: 1.82 g/cm³
• LogP: 1.93700

Purity/Quality:

98%min ^*data from raw suppliers

2-Acetamido-5-bromothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ACETAMIDO-5-BROMOTHIAZOLE

There total 7 articles about 2-ACETAMIDO-5-BROMOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-2-aminothiazole (3034-22-8) + acetic anhydride (108-24-7) → 2-acetamido-5-bromothiazole (7336-54-1)

Guidance literature:

at 100 ℃; for 3h;

Reference yield: 80.0%

5-bromo-2-aminothiazole (3034-22-8) → 2-acetamido-5-bromothiazole (7336-54-1)

Guidance literature:

With pyridine; acetic anhydride; In dichloromethane;

Reference yield:

5-bromothiazol-2-amine hydrobromide (61296-22-8) + acetic anhydride (108-24-7) → 2-acetamido-5-bromothiazole (7336-54-1)

Guidance literature:

5-bromothiazol-2-amine hydrobromide; acetic anhydride; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 18.5h;

With sodium hydroxide; In dichloromethane; water; pH=8;

upstream raw materials:

5-bromo-2-aminothiazole

2-acetamidothiazole

acetic anhydride

2-bromo-4-aminothiazole

Downstream raw materials:

(S)-N-(5-bromothiazol-2-yl)-N-(2-(1,3-dioxoisoindolin-2-yl)-3-phenylpropyl)acetamide

C₂₈H₂₈F₃N₅O₂S

N-[5-(3-chloro-4-methoxy-benzenesulfonyl)-thiazol-2-yl]-acetamide

N-(5-benzenesulfonyl-thiazol-2-yl)-acetamide

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF AS PI3K INHIBITOR". Paragraph 0176-0178. . Retrieved 2021/06/03.
• 2、 -. "NOVEL COMPOUNDS THAT MODULATE PPARγ TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS". Page 60. . Retrieved 2008/06/13.