Cyclohexanemethanol, 4,4-difluoro- (9CI)

Base Information

• Chemical Name: Cyclohexanemethanol, 4,4-difluoro- (9CI)
• CAS No.: 178312-48-6
• Molecular Formula: C7H12F2O
• Molecular Weight: 150.168
• Hs Code.: 2906199090
• Mol file: 178312-48-6.mol

Synonyms:(4,4-Difluorocyclohexyl)methanol;

Chemical Property of Cyclohexanemethanol, 4,4-difluoro- (9CI)

Chemical Property:

• Refractive Index: n20/D1.431
• Boiling Point: 181.4 °C at 760 mmHg
• PKA: 15.05±0.10(Predicted)
• Flash Point: 63.5 °C
• PSA: 20.23000
• Density: 1.11 g/cm³
• LogP: 1.80420
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4,4-Difluorocyclohexyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (4,4-Difluorocyclohexyl)methanol acts as a reagent in the preparation and anti-HIV activity of fluorinated betulinic acid derivatives.

Technology Process of Cyclohexanemethanol, 4,4-difluoro- (9CI)

There total 10 articles about Cyclohexanemethanol, 4,4-difluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4,4-difluorocyclohexanecarboxylic acid (122665-97-8) → (4,4-difluorocyclohexyl)methanol (178312-48-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 83.0%

ethyl 4,4-difluorocyclohexane-1-carboxylate (178312-47-5) → (4,4-difluorocyclohexyl)methanol (178312-48-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 25 ℃; for 4h;

Reference yield: 81.0%

methyl 4,4-difluorocyclohexane-1-carboxylate (121629-14-9) → (4,4-difluorocyclohexyl)methanol (178312-48-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

ethyl 4,4-difluorocyclohexane-1-carboxylate

p-toluenesulfonyl chloride

4,4-difluorocyclohexanecarboxylic acid

ethyl 4-oxocyclohexane-1-carboxylate

Downstream raw materials:

4,4-difluorocyclohexane carboxyaldehyde

C₂₀H₂₇F₂N₅O₄

Refernces

• 1、 -. "HYDROXYL PURINE COMPOUNDS AND USE THEREOF". Paragraph 0096; 0097; 0098. . Retrieved 2018/04/05.
• 2、 -. "OXABOROLE ESTERS AND USES THEREOF". Page/Page column 99. . Retrieved 2017/12/05.