(1R,3S)-3-AMINOCYCLOPENTANOL HYDROCHLORIDE

Base Information

• Chemical Name: (1R,3S)-3-AMINOCYCLOPENTANOL HYDROCHLORIDE
• CAS No.: 124555-33-5
• Molecular Formula: C5H11NO
• Molecular Weight: 137.61
• Hs Code.: 2926907090
• Mol file: 124555-33-5.mol

Synonyms:Cyclopentanol,3-amino-, hydrochloride, trans-;

Chemical Property of (1R,3S)-3-AMINOCYCLOPENTANOL HYDROCHLORIDE

Chemical Property:

• Boiling Point: 179.4 °C at 760 mmHg
• Flash Point: 62.3 °C
• PSA: 46.25000
• Density: 1.084 g/cm³
• LogP: 0.55880
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-3-Aminocyclopentanol hydrochloride 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1R,3S)-3-Aminocyclopentanol Hydrochloride is used to for the preparation of 6-Aminopyridin-3-ylthiazoles as a method of treating or ameliorating a syndrome, disorder or disease related rheumatoid arthritis or psoriasis.

Technology Process of (1R,3S)-3-AMINOCYCLOPENTANOL HYDROCHLORIDE

There total 33 articles about (1R,3S)-3-AMINOCYCLOPENTANOL HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(1S,3R)-3-hydroxycyclopentyl-1-carbamic acid tert-butyl ester (167465-99-8,1154870-59-3,207729-04-2) → (1R,3S)-3-amino-1-cyclopentanol hydrochloride (1279032-31-3,124555-33-5,1259436-59-3,1523541-74-3,1284248-73-2,1523530-42-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield: 82.0%

C13H17NO3 (1445796-28-0) → rac-3-aminocyclopentanol hydrochloride (1184919-69-4,124555-33-5,1259436-59-3,1523541-74-3,1284248-73-2,1523530-42-8)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Reflux;

Reference yield: 68.9%

(R)-2-hydroxy-N-((1S,3R)-3-hydroxycyclopentyl)propanamide → (1R,3S)-3-amino-1-cyclopentanol hydrochloride (1279032-31-3,124555-33-5,1259436-59-3,1523541-74-3,1284248-73-2,1523530-42-8)

Guidance literature:

With hydrogenchloride; In methanol; at 25 ℃;

upstream raw materials:

(1S,3R)-3-aminocyclopentane-1-ol

tert-butyl N-[(1R,3S)-3-hydroxycyclopentyl]carbamate

(1S,3S)-3-(tert-butyl-dimethyl-silanyloxy)-cyclopentylamine

(1S,3R)-3-hydroxycyclopentyl-1-carbamic acid tert-butyl ester

Downstream raw materials:

C₁₈H₁₇ClF₂N₂O₄S

(2R,5S,13aR)-8-methoxy-7,9-dioxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1‘,2’:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide

Refernces

• 1、 -. "Method for preparing (1R, 3S)-3-aminocyclopentanol hydrochloride". Paragraph 0030; 0046-0048; 0054-0058. . Retrieved 2021/03/31.
• 2、 -. "Preparation method of optically pure cyclic amino alcohol and salt thereof". Paragraph 0104-0108. . Retrieved 2020/01/25.