2-(Chloromethyl)-4-ethoxypyridine

Base Information

• Chemical Name: 2-(Chloromethyl)-4-ethoxypyridine
• CAS No.: 159996-13-1
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Mol file: 159996-13-1.mol

Synonyms:2-(Chloromethyl)-4-ethoxy-pyridine;

Chemical Property of 2-(Chloromethyl)-4-ethoxypyridine

Chemical Property:

• Vapor Pressure: 0.0253mmHg at 25°C
• Refractive Index: 1.514
• Boiling Point: 256 °C at 760 mmHg
• PKA: 5.02±0.20(Predicted)
• Flash Point: 108.6 °C
• PSA: 22.12000
• Density: 1.137 g/cm³
• LogP: 2.21910

Purity/Quality:

99% ^*data from raw suppliers

2-(chloromethyl)-4-ethoxy-Pyridinehydrochloride 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Chloromethyl)-4-ethoxypyridine

There total 3 articles about 2-(Chloromethyl)-4-ethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-ethoxypyridin-2-yl)methanol (19677-69-1) → 2-(chloromethyl)-4-ethoxypyridine (159996-13-1)

Guidance literature:

With thionyl chloride; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/jm00081a004

Reference yield:

4-ethoxy-2-methyl-pyridine-1-oxide (26883-31-8) → 2-(chloromethyl)-4-ethoxypyridine (159996-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: AcOH / 120 °C

2: 2N aq. NaOH / methanol / 2 h / 25 °C

3: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; acetic acid; In methanol; dichloromethane;

DOI:10.1021/jm00081a004

Reference yield:

Acetic acid 4-ethoxy-pyridin-2-ylmethyl ester → 2-(chloromethyl)-4-ethoxypyridine (159996-13-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 2N aq. NaOH / methanol / 2 h / 25 °C

2: SOCl₂ / CH₂Cl₂ / 2 h / 25 °C

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane;

DOI:10.1021/jm00081a004

upstream raw materials:

(4-ethoxypyridin-2-yl)methanol

4-ethoxy-2-methyl-pyridine-1-oxide

Downstream raw materials:

4-[(4-ethoxypyridin-2-yl)methoxy]-N-[2-methyl-5-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide

Refernces