Bicalutamide Sulfoxide

Base Information

• Chemical Name: Bicalutamide Sulfoxide
• CAS No.: 945419-64-7
• Molecular Formula: C18H14 F4 N2 O3 S
• Molecular Weight: 414.38
• Mol file: 945419-64-7.mol

Synonyms:Bicalutamide Sulfoxide;

Chemical Property of Bicalutamide Sulfoxide

Chemical Property:

• Melting Point: 156-159°C
• PSA: 112.89000
• LogP: 4.72868
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly, Sonicated), Methanol (Slightly)

Purity/Quality:

> 95% ^*data from raw suppliers

rel-(R*,S*)-BicalutamideSulfoxide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An impurity of Bicalutamide Bicalutamide Sulfoxide is a derivative of Bicalutamide (B382000), non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal).

Technology Process of Bicalutamide Sulfoxide

There total 2 articles about Bicalutamide Sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide (90356-78-8) → N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfinyl-2-hydroxy-2-methyl-propanamide (945419-64-7,1080647-25-1) + Bicalutamide (90357-06-5)

Guidance literature:

With urea hydrogen peroxide adduct; In tetrahydrofuran; formic acid; water; at 27 - 35 ℃; for 1h;

Reference yield:

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide (90356-78-8) → N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfinyl-2-hydroxy-2-methyl-propanamide (945419-64-7,1080647-25-1)

Guidance literature:

With sodium peroxoborate tetrahydrate; acetic acid; at 20 ℃; for 2.75h;

DOI:10.1080/00397910802519208

upstream raw materials:

N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfanyl]-2-hydroxy-2-methylpropanamide

Refernces

• 1、 -. "A PROCESS FOR THE PRODUCTION OF HIGHLY PURE N-(4-CYANO-3-TRIFLUOROMETHYLPHENYL)-3-(4-FLUOROPHENYLTHIO)-2-HYDROXY-2-METHYLPROPANAMIDE". Page 7-8. . Retrieved 2008/06/13.